Gastroenterology straddles internal medicine and surgery,

two disciplines known for their pronounced mutual distrust. Yet, treatment of complex gastrointestinal disorders demand new development that only close cooperation of different disciplines can bring about. With a vision to solve digestive disease problems, Professor Joseph Sung, founder of the Institute, assembled experts from various specialties to create a productive multidisciplinary research environment.

The Institute of Digestive Disease was thus born. Its establishment cemented the alliance of medical and surgical gastroenterologists and other healthcare professionals. Since the beginning, they have been working closely together, sharing resources and expertise. Our strong culture of collaboration and firm focus on interdisciplinary work have helped us produced research that changed local and global clinical practices that ultimately contribute to our goal to cure and alleviate suffering afflicted by digestive diseases.

Prof Jun YU

Director of Institute of Digestive Disease

Contact Information
Tel: (852) 3763 6099
Email: junyu@cuhk.edu.hk

CUHK Employment

  • Director, Institute of Digestive Disease
  • Professor, Department of Medicine and Therapeutics
  • Director, Research Laboratory of Institute of Digestive Disease
  • Director, State Key Laboratory of Digestive Disease (CUHK)
  • Assistant Dean (Mainland Affairs), Faculty of Medicine

Honorary appointments

  • Cheung Kong Scholar Chair Professor (Ministry of High Education, China)
  • Honorary Professor, The University of Hong Kong
  • Visiting Professor, Beijing University
  • Visiting Professor, Sun-Yat Sen University
  • Visiting Professor, Zhejiang University
  • Pao Yue-Kong Chair Professor, Ningbo University

Expertise

  • Gastrointestinal cancer
  • Fatty Liver Disease
  • Microbiome in Cancer

Education and Qualifications

MB, MM (Heibei Med); MD, PhD (Tongji Med)

Research Interests

  • Genomic and epigenomic alterations in gastrointestinal (GI) cancer
  • Gut microbiome, bacteria/host interaction during cancer development
  • Non-alcoholic fatty liver disease and liver cancer in relation to the mechanisms and therapeutic targets
  • Biomarkers for early detection and treatment of GI cancer

Additional Information

Award & Honour
  • Research Excellence Award CUHK, 2019
  • Ho Leung Ho Lee Fund Science and Technology Progress Award (Medicine), 2018
  • American Gastroenterology Association Council Oncology Research Mentor Award, 2017
  • The WuXi PharmaTech Life Science and Chemistry Award, 2017
  • The State Scientific and Technological Progress Award (Natural Science), 2016
  • The State Scientific and Technological Progress Award (Innovation Team), 2016
  • Croucher Senior Research Fellowship Hong Kong, 2016
  • Outstanding Fellow of Faculty of Medicine CUHK, 2015
  • Ministry of Education Higher Education Outstanding Scientific Research Output Award - First-class Award in Natural Sciences, 2014
  • The State Scientific and Technological Progress Award (Science and Technology Progress), 2012
  • Ministry of Education Higher Education Outstanding Scientific Research Output Award - First-class Award in Scientific & Technological Progress, 2012
  • Research Output Award - First-class Award in Natural Sciences, 2010
  • Research Excellence Award CUHK, 2009
Professional Service
  • Council member of American Gastroenterology Association (AGA) Oncology USA
  • Council member of AGA Microbiome and Microbial Diseases USA
  • Council member of The International Cancer Microbiome Consortium UK
  • Associate Chairman of National Cancer and Microbiome Association China
  • Associate Chairman of HK Scientist Association
  • Executive Member of Hong Kong Cancer Institute (HKCI)
  • President of Hong Kong Immunology Association, 2017-2018
  • President of Hong Kong Flow Cytometry Association, 2015-2016
  • Associate Editor for Oncogene, Life Science (2011-2015); Editor for Gut, Scientific Reports, JGH etc.
Academic Engagement in CUHK
  • Assistant Dean, Faculty of Medicine
  • Executive Member, Faculty of Medicine
  • Advisor of Female Professorial Staff Support Network, CUHK
  • Member of Publication Ethics Committee, CUHK

Research and Publications

  1. Long X, Wong CC, Li T, Chu E, Szeto CH, Go MMY, Coker O, Chan A, Chan F, Sung JJY, Yu J. Peptostreptococcus anaerobius promotes colorectal carcinogenesis and modulates tumor-immunity by activating PI3K/Akt signaling via its PCWBR2 adhesin. Nat Microbiol. 2019 Sep 9. doi: 10.1038/s41564-019-0541-3.
  2. Zhang X, Fan L, Wu J, Xu H, Leung WY, Fu K, Wu J, Liu K, Kwan M, Yang X, Han J, Ren J, Yu J. Macrophage p38α promotes nutritional steatohepatitis through M1 polarization. J Hepatol. 2019 Jul;71(1):163-174.
  3. Coker OO, Nakatsu G, Dai RZ, Wu WKK, Wong SH, Ng SC, Chan FKL, Sung JJY, Yu J. Enteric fungal microbiota dysbiosis and ecological alterations in colorectal cancer. Gut. 2019 Apr;68(4):654-662.
  4. Liang JQ, Teoh N, Xu L, Pok S, Li X, Chu ESH, Chiu J, Dong L, Arfianti E, Haigh WG, Yeh MM, Ioannou GN, Sung JJY, Farrell G, Yu J. Dietary cholesterol promotes steatohepatitis related hepatocellular carcinoma through dysregulated metabolism and calcium signaling. Nat Commun. 2018 Oct 26;9(1):4490.
  5. Nakatsu G, Zhou H, Wu WKK, Wong SH, Coker OO, Dai Z, Li X, Szeto CH, Sugimura N, Yuen-Tung Lam T, Chi-Shing Yu A, Wang X, Chen Z, Chi-Sang Wong M, Ng SC, Chan MTV, Chan PKS, Leung Chan FK, Jao-Yiu Sung J, Yu J. Alterations in Enteric Virome Associate With Colorectal Cancer and Survival Outcomes. Gastroenterology. 2018 Aug;155(2):529-541.e5.
  6. Coker OO, Dai Z, Nie Y, Zhao G, Cao L, Nakatsu G, Wu WK, Wong SH, Chen Z, Sung JJY, Yu J. Mucosal microbiome dysbiosis in gastric carcinogenesis. Gut. 2018 Jun;67(6):1024-1032.
  7. Sun W, Zhang Y, Wong KC, Liu K, Yang Y, Wu B, Tong JH, Chan AW, Chan HL, Yu J. Increased expression of GATA Zinc Finger Domain Containing 1 via gene amplification promotes liver cancer by directly inducing PRL3. Hepatology. 2018 Jun;67(6):2302-2319.
  8. Liu D, Wong CC, Fu L, Chen H, Zhao L, Li C, Zhou Y, Zhang Y, Xu W, Yang Y, Wu B, Cheng G, Lai PB, Wong N, Sung JJY, Yu J. Squalene epoxidase drives NAFLD-induced hepatocellular carcinoma and is a pharmaceutical target. Sci Transl Med. 2018 Apr 18;10(437).
  9. Wong SH, Zhao L, Zhang X, Nakatsu G, Han J, Xu W, Xiao X, Kwong TN, Tsoi H, Wu WK, Benhua Z, Chan FK, Sung JJ, Wei H, Yu J. Gavage of Fecal Samples From Patients with Colorectal Cancer Promotes Intestinal Carcinogenesis in Germ-free and Conventional Mice. Gastroenterology. 2017 Dec;153(6):1621-1633.e6.
  10. Tsoi H, Chu ES, Zhang X, Sheng J, Nakatsu D, Ng SC, Chan AW, Chan FK, Sung JJ, Yu J. Peptostreptococcus anaerobius Induces Intracellular Cholesterol Biosynthesis in Colon Cells to Induce Proliferation and Causes Dysplasia in Mice. Gastroenterology. 2017 May;152(6):1419-1433.e5.

Prof Jun YU

Director

Institute of Digestive Disease

Prof Joseph J.Y. SUNG

Emeritus Professor

Contact Information
Tel: (852)3505 3136
Email: jjysung@cuhk.edu.hk

 

CUHK APPOINTMENT

  • Emeritus Professor, Department of Medicine and Therapeutics

Honorary appointments

  • Honorary Advisor, Chow Yuk Ho Technology Centre for Innovative Medicine, Faculty of Medicine, CUHK
  • Honorary Consultant, New Territories East Cluster, Hospital Authority, HKSAR
  • Justice of the Peace, Hong Kong SAR Government
  • Li Dak Sum Chair Professor in Medicine, Ningbo University, Ningbo
  • Honorary Professor, Li Ka Shing Faculty of Medicine, The University of Hong Kong
  • Honorary Professor, Macau University of Science and Technology, Macau
  • Honorary Professor, Tsinghua University, Beijing
  • Honorary Professor, Huaqiao University, Fujian

Expertise

Gastroenterology and Hepatology

Education and Qualifications

MBBS (HKU), PhD (UCalgary), FHKAM, FRCP (Edin), FHKCP, MD (CUHK), FRCP (Lond), FACG, FRACP, FRCP (Thai), FRCP (Glasg), FAGA, FHKS, FJGES

Research Interests

  • Intestinal bleeding, Helicobacter Pylori, peptic ulcer, hepatitis B, colorectal cancer, and other cancers related to the digestive system.

Additional Information

Award & Honour
  • Outstanding Staff and Team Award: Hospital Authority, Hong Kong (1998)
  • The State Scientific and Technological Progress Award – Second Prize”, The State Council, The People’s Republic of China (2003)
  • Asian Hero Award 2003. Time Magazine (2003)
  • Vice Chancellor’s Exemplary Teaching Award 2003, The Chinese University of Hong Kong (2003)
  • Silver Bauhinia Star, The Government of the Hong Kong Special Administrative Region (2004)
  • Cheung Kong Achievement Award, Ministry of Education, The People’s Republic of China and Li Ka--shing Foundation (2006)
  • The Most Outstanding Contribution Award (Clinical Therapeutics), Health Research Symposium 2007 (2007)
  • The State Scientific and Technological Progress Award – Second Prize on “Innovative Non-surgical Treatment of Peptic Ulcer Bleeding”, The State Council, The People’s Republic of China (2007)
  • Marshall and Warren Lecture Award, Journal of Gastroenterology and Hepatology Foundation (2009)
  • Endoscopy Award, German Society of Gastroenterology (2009)
  • Academician of Chinese Academy of Engineering (CAE), The People’s Republic of China (2011)
  • The Ho Leung Ho Lee Foundation Scientific and Technology Progress Award, The Ho Leung Ho Lee Foundation, The People’s Republic of China (2011)
  • Higher Education Outstanding Scientific Research Output Awards in Natural Science – First Class, The Ministry of Education, The People’s Republic of China (2011)
  • Academician of International Eurasian Academy of Sciences (IEAS) (2012)
  • Higher Education Outstanding Scientific Research Output Awards in Technological Advancement – Second Class, The Ministry of Education, The People’s Republic of China (2012)
  • Higher Education Outstanding Scientific Research Output Awards in Technological Advancement – First Class, The Ministry of Education, The People’s Republic of China (2013)
  • Master of the World Gastroenterology Organisation (WGO) Award 2013, World Gastroenterology Organisation (2013)
  • World Outstanding Chinese Award, World Chinese Business Investment Foundation (2013)
  • 2014 Fulbright Hong Kong Distinguished Scholar Award, The Fulbright Program (2014)
  • Higher Education Outstanding Scientific Research Output Awards in Scientific and Technological Progress – First Class, The Ministry of Education, The People’s Republic of China (2015)
  • Honorary Fellow, Hong Kong College of Physicians (2015)
  • The State Natural Science Award – Second Prize, The State Council, The People’s Republic of China (2016)
  • The State Scientific and Technological Progress Award - Innovation Team, State Council, People’s Republic of China (2016)
  • International Herbert Falk Award, Falk Foundation e.V. Freiburg (2017)
  • Highly Cited Researchers (Cross Field) 2018 by Clarivate Analytics (2018)
  • 2018 Doctor of Education honoris causa, University of Macau, Macau SAR (2018)
  • 2019 Honorary Doctorate of Science, University of Exeter, United Kingdom (2019)
  • Highly Cited Researchers (Cross Field) 2019 by Clarivate Analytics (2019)
  • Highly Cited Researchers (Clinical Medicine) 2020 by Clarivate Analytics (2020)
  • Highly Cited Researchers (Clinical Medicine) 2021 by Clarivate Analytics (2021)

Research and Publications

  1. Sung JJY, Chung SC, Lai CW, Chan FK, Leung JW, Yung MY, Kassianides C, Li AK. (1993). Octreotide infusion or emergency sclerotherapy for variceal haemorrhage. Lancet., 342(8872), 637-41.
  2. Sung JJY, Chung SCS, Yung MY, Lai CW, Lau JYW, Lee YT, Leung VKS, Li MKK, Li AKC. (1995). Prospective randomised study of effect of octreotide on rebleeding from oesophageal varices after endoscopic banding ligation. Lancet., 346(8991-8992), 1666-1669.
  3. Sung JJY, Chung SCS, Ling TKW, Yung MY, Leung VKS, Ng EKW, Li KK, Cheng AFB, Li AKC. (1995). Antibacterial treatment of gastric ulcers associated with Helicobacter pylori. The New England Journal of Medicine., 332(3), 139-142.
  4. Sung JJY. (2002). Acupunture for gastrointestinal disorders: myth or magic? Gut, 51(5), 617-9.
  5. Lee, N, Hui, D, Wu, A, Chan, P, Cameron, P, Joynt, GM, Ahuja, A, Yung, MY, Leung, CB, To, KF, Lui, SF, Szeto, CC, Chung, S, Sung, JJY (2003). A major outbreak of severe acute respiratory syndrome in Hong Kong. The New England Journal of Medicine., 348(20), 1986-1994.
  6. Sung JJY. (2004). Westernisation of gastrointestinal diseases in Asia. Gut., 53(1), 152.
  7. Sung JJY, Tsoi KK, Lai LH, Wu JC, Lau JY. (2007). Endoscopic clipping versus injection and thermo-coagulation in the treatment of non-variceal upper gastrointestinal bleeding: a meta-analysis. Gut., 56(10), 1364-73.
  8. Sung JJY, Lau JYW, Young GP, Sano Y, Chiu HM, Byeon JS, Yeoh KG, Goh KL, Sollano J, Rerknimitr R, Matsuda T, Wu KC, Ng S, Leung SY Makharia G, Chong VH, Ho KY, Brooks D, Lieberman DA, Chan FKL. (2008). Asia Pacific Working Group on Colorectal Cancer. Asia Pacific Consensus Recommendations for Colorectal Cancer Screening. Gut., 57(8), 1166-76.
  9. Sung JJY. Chan FK. Chen M. Ching JY. Ho KY. Kachintorn U. Kim N. Lau JY. Menon J. Rani AA. Reddy N. Sollano J. Sugano K. Tsoi KK. Wu CY. Yeomans N. Vakil N. Goh KL. (2011). Asia-Pacific Working Group consensus on non-variceal upper gastrointestinal bleeding. Asia-Pacific Working Group. Gut., 60(9), 1170-7.
  10. Sung JJY, Chiu PC, Chan FKL, et al Asia-Pacific working group consensus on non-variceal upper gastrointestinal bleeding: an update 2018. Gut Published Online First: 24 April 2018. doi: 10.1136/gutjnl-2018-316276

Prof Joseph J.Y. SUNG

Emeritus Professor

Division of Gastroenterology and Hepatology
Department of Medicine and Therapeutics

Prof. Francis K.L. Chan

Division of Gastroenterology and Hepatology, Department of Medicine and Therapeutics

Contact Information
Email: fklchan@cuhk.edu.hk

CUHK Employment

  • Former Dean, Faculty of Medicine
  • Choh-Ming Li Professor of Medicine and Therapeutics
  • Director, Centre for Gut Microbiota Research

Expertise

  • Peptic ulcer bleeding
  • Helicobacter pylori
  • Endoscopic therapy
  • Colorectal cancer

Education and Qualifications

MBChB(Hons)(CUHK), MD(CUHK), DSc(CUHK), FHKCP, FHKAM(Med), FRCP(Irel), FRCP(Edin), FACG, FRCP(Lond)

Research Interests

  • Peptic ulcer bleeding
  • Helicobacter pylori
  • Endoscopic therapy
  • Colorectal cancer

Additional Information

Award & Honour
  • Honorary Doctorate Degree, Osaka City University, 2019
  • Honorary Fellow of Internal Medicine, Royal College of Physicians of Thailand, 2018
  • International Leadership Award, The American College of Gastroenterology, 2018
  • 27th Seah Cheng Siang Memorial Lecturer, 2017
  • 19th Vikit Viranuvatti’s Lecturer, 2016
  • JGHF Marshall and Warren Lecturer, 2011
  • Andy Martynoga Memorial Lecturer, 2008
  • Croucher Senior Medical Research Fellowship, 2007-2008
  • The State Scientific and Technological Progress Award, National Office for Science and Technology Awards of PRC, 2007
  • David Y. Graham Lecturer, The American College of Gastroenterology, 2005
Professional Service
  • Board Member, Hong Kong Hospital Authority
  • Member, Colorectal Cancer Screening Pilot Programme Task Force, Department of Health
  • Permanent Member, Expert Panel of Central Research Working Group for Hospital Authority, Chinese Medicine Research, Hong Kong Hospital Authority
  • Member, Governing Board, Hong Kong Jockey Club Disaster Preparedness and Response Institute, Hong Kong Academy of Medicine
  • Convenor, Endoscopy Task Force of Project Steering Committee on Standards for Ambulatory Facilities, Department of Health
  • Ex-officio Member, Research Fellowship Assessment Panel, Food and Health BureauMember (Oct 2017 – Sep 2020), External Review Committee, Hong Kong Sanatorium & Hospital
  • Honorary Advisor, Hong Kong Association for Integration of Chinese-Western Medicine
  • Advisor on Education, Peking Union Medical College (PUMC)
  • Assessment Expert of Health Research Projects (Mar 2013 – Feb 2016), Technology Education Unit of Ministry of Health of PRC
  • Panelist, Global Panel of Clinicians and Clinical Researchers, Nature [to help Nature select a list of high-quality clinical journals for inclusion in the Nature Index]
  • Nominator, 2016 Future Science Prize, Beijing, China
  • External Assessor in Gastroenterology, University of Malaya, Malaysia
  • Leader, Task Force for Developing Clinical Practice Guidelines for Clinicians in Asia Pacific Countries, appointed by Asian Pacific Association of Gastroenterology and the Asian Pacific Society of Digestive Endoscopy
  • Member (Jul 2018 – Apr 2021), Open Fund Large Collaborative Grant Review Panel, National Medical Research Council, Ministry of Health, Singapore

Research and Publications

Professor Chan has published more than 500 full scientific articles in high impact factor international journals such as New England Journal of Medicine, Lancet and Gastroenterology with an H-index 94.
  1. Chan FK, et al. Gastrointestinal safety of celecoxib versus naproxen in patients with cardiothrombotic diseases and arthritis after upper gastrointestinal bleeding (CONCERN): an industry-independent, double-blind, double-dummy, randomised trial. Lancet 2017;389:2375-82.
  2. Chan FK, et al. Celecoxib versus omeprazole and diclofenac in patients with osteoarthritis and rheumatoid arthritis (CONDOR): arandomised trial. Lancet 2010;376:173-9.
  3. Chan FK, et al. Combination of a cyclo-oxygenase-2 inhibitor and a proton-pump inhibitor for prevention of recurrent ulcer bleeding in patients at very high risk: a double-blind, randomised trial. Lancet 2007;369:1621-6.
  4. Chan FK, et al. Clopidogrel versus aspirin and esomeprazole to prevent recurrent ulcer bleeding. N Engl J Med 2005;352:238-44.
  5. Chan FK, et al. Eradication of Helicobacter pylori and the risk of peptic ulcers in patients starting long-term treatment with non-steroidal anti-inflammatory drugs: A randomised trial. Lancet 2002;359:9-13.
  6. Chan FK, et al. Celecoxib versus diclofenac and omeprazole in reducing the risk of recurrent ulcer bleeding in patients with arthritis. N Engl J Med 2002;347:2104-10.
  7. Chan FK, et al. Preventing recurrent upper gastrointestinal bleeding in patients with Helicobacter pylori infection who are taking low-dose aspirin or naproxen. N Engl J Med 2001;344:967-73.
  8. Chan FK, et al. Randomised trial of eradication of Helicobacter pylori before non-steroidal anti-inflammatory drug therapy to prevent peptic ulcers. Lancet 1997;350:975-97.

Prof Francis K.L. CHAN

Professor

Division of Gastroenterology and Hepatology
Department of Medicine and Therapeutics

Professor Philip W.Y. CHIU

Division of Upper Gastrointestinal and Metabolic Surgery, Department of Surgery

Contact Information
Email: dean@med.cuhk.edu.hk

CUHK Employment

  • Dean, Faculty of Medicine
  • Shun Hing Education and Charity Fund Professor of Robotic Surgery
  • Director, Multi-Scale Medical Robotics Center
  • Director, Chow Yuk Ho Technology Centre for Innovative Medicine

Honorary appointments

  • Honorary Consultant, Department of Surgery, Prince of Wales Hospital
  • Honorary Director of Endoscopy, Prince of Wales Hospital and New Territories East Cluster, Hospital Authority

Expertise

  • Upper Gastrointestinal Surgery
  • Minimally Invasive and Robotic Surgery
  • Endoscopic Surgery

Education and Qualifications

MBChB, MD (CUHK), FRCSEd, FCSHK, FRCSEd (Gen), FHKAM (Surgery)

Research Interests

  • Early Diagnosis and Treatment of Upper GI Cancers
  • Minimally Invasive and Robotic Surgery
  • Endoscopic Submucosal Dissection, Peroral Endoscopic Myotomy and Submucosal Endoscopic Tumour resection.

Additional Information

Award & Honour
  • Karl-Storz-Harold Hopkins Golden Telescope Award, The Hamlyn Symposium on Medical Robotics, Imperial College London, 2023
  • Honorary Member, European Association for Endoscopic Surgery and other Interventional Techniques (EAES), 2023
  • Gold Medal with Congratulations of the Jury, Gold Medal and 2 Silver Medals, International Exhibition of Inventions of Geneva, 2023
  • International Honorary Member, Japan Society of Endoscopic Surgery (JSES), 2021
  • Outstanding Team Award (PWH Endoscopy), Hospital Authority, Hong Kong, 2021
  • Bronze Medal, International Exhibition of Inventions of Geneva, 2021
  • Spirit of Hong Kong Award on Innovation, 2020
  • Gold Medal with Congratulations of the Jury, 47th International Exhibition of Inventions of Geneva, 2019
  • JGH Emerging Leader Lectureship Award, Asia Pacific Digestive Week, 2016
  • Global Chinese Outstanding Youth Award, 2016
  • Outstanding contribution award, Chinese Society of Digestive Endoscopy, 2015
  • Champion of the World Cup of Endoscopy, American Society of Gastrointestinal Endoscopy, 2012
  • Higher Education Outstanding Scientific Research Output Award (Science and Technology) - Second-class Award in Technological Advancement, Ministry of Education of PRC, 2011
  • Research abstract awarded Best of Digestive Disease Week, United States, 2011
  • State Scientific & Technological Progress Award, State Council of PRC, 2007
Professional Service
  • Member, Steering Committee, Health and Medical Innovation Development, Health Bureau, HKSAR Government
  • Cluster Director of Endoscopy, New Territories East Cluster, Hong Kong Hospital Authority
  • Director of Endoscopy, Prince of Wales Hospital
  • Member, Research Projects Assessment Panel, Innovation and Technology Fund, Innovation and Technology Commission, HKSAR Government
  • Member, Institute for Translational Research Incu-Bio Assessment Panel, Hong Kong Science and Technology Parks Corporation
  • Founder and Executive Board Member, The Upper GI International Robotic Association (UGIRA)
  • President of Endoscopic and Laparoscopic Surgeons of Asia (ELSA) (2021-2023)
  • Chairman of Surgical Endoscopy, World Endoscopy Organization
  • Executive Councillor, Asia Diabetes Foundation
  • Co-editor, Endoscopy
  • External Assessor, University of Malaya, Malaysia

Research and Publications

  1. Cao J, Yip HC, Chen Y, Scheppach M, Luo X, Yang H, Cheng MK, Long Y, Jin Y, Chiu PW, Yam Y, Meng HM, Dou Q. Intelligent surgical workflow recognition for endoscopic submucosal dissection with real-time animal study. Nat Commun. 2023 Oct 21;14(1):6676. doi: 10.1038/s41467-023-42451-8. PMID: 37865629; PMCID: PMC10590425.
  2. Lau LHS, Ho JCL, Lai JCT, Ho AHY, Wu CWK, Lo VWH, Lai CMS, Scheppach MW, Sia F, Ho KHK, Xiao X, Yip TCF, Lam TYT, Kwok HYH, Chan HCH, Lui RN, ChanT-T, Wong MTL, Ho M-F, Ko RCW, Hon S-F, Chu S, Futaba K, Ng SSM, Yip H-C, Tang RSY, Wong VWS, Chan FKL, *Chiu PWY, (ENDOAID-TRAIN study group), Effect of real-time computer-aided polyp detection system (ENDO-AID) on adenoma detection in endoscopists-in-training: a randomized trial, Clinical Gastroenterology and Hepatology (2023), doi: https://doi.org/10.1016/j.cgh.2023.10.019
  3. *Chiu PWY, Ho KY, Phee SJ. Colonic endoscopic submucosal dissection using a novel robotic system (with video). GastrointestEndosc. 2021 May;93(5):1172-1177.
  4. Xu X, Xia X, Zhang K, Rai A, Li Z, Zhao P, Wei K, Zou L, Yang B, Wong WK, *Chiu PW, Bian L. Bioadhesive hydrogels demonstrating pH-independent and ultrafast gelation promote gastric ulcer healing in pigs. Sci Transl Med. 2020 Aug 26;12(558):eaba8014
  5. Xia X, Chan KF, Wong GTY, Wang P, Liu L, Yeung BPM, Ng EKW, Lau JYW, *Chiu PWY. Mesenchymal Stem Cells Promote Healing of Nonsteroidal Anti-Inflammatory Drug-Related Peptic Ulcer Through Paracrine Actions in Pigs. Sci TranslMed. 2019 Oct 30;11(516):eaat7455.
  6. *Chiu PWY, Ng SC, Inoue H, Reddy DN, Ling Hu E, Cho JY, Ho LK, Hewett DG, Chiu HM, Rerknimitr R, Wang HP, Ho SH, Seo DW, Goh KL, Tajiri H, Kitano S, Chan FKL. Practice of endoscopy during COVID-19 pandemic: position statements of the Asian Pacific Society for Digestive Endoscopy (APSDE-COVID statements). Gut. 2020 Jun;69(6):991-996. doi: 10.1136/gutjnl-2020-321185.
  7. *Chiu PWY, Uedo N, Singh R, Gotoda T, Ng EKW, Yao K, Ang TL, Ho SH, Kikuchi D, Yao F, Pittayanon R, Goda K, Lau JYW, Tajiri H, Inoue H. An Asian consensus on standards of diagnostic upper endoscopy for neoplasia. Gut. 2019 Feb;68(2):186-197. doi: 10.1136/gutjnl-2018-317111.
  8. *Chiu PWY, Yip HC, Teoh AYB, Wong VWY, Chan SM, Wong SKH, Ng EKW. Per oral endoscopic tumor (POET) resection for treatment of upper gastrointestinal subepithelial tumors. Surg Endosc. 2019 Apr;33(4):1326-1333.
  9. Takeshita N, Ho KY, Phee SJ, Chiu PW. Feasibility of performing esophageal endoscopic submucosal dissection using master and slave transluminal endoscopic robot. Endoscopy 2017; Feb; 49(S01):E27-28.
  10. *Chiu PW, Joeng HK, Choi CL, Tsoi KK, Kwong KH, Lam SH, Sung JJ. High dose omeprazole infusion compared with scheduled second look endoscopy for prevention of peptic ulcer rebleeding: a randomized controlled trial. Endoscopy. 2016 Aug;48(8):717-22.
*corresponding author

Prof Philip W.Y. CHIU

Professor

Division of Upper Gastrointestinal and Metabolic Surgery
Department of Surgery

Prof Henry L.Y. CHAN

Division of Gastroenterology and Hepatology, Department of Medicine and Therapeutics

Contact Information
Email: hlychan@cuhk.edu.hk

CUHK Employment

  • Honorary Professor, Department of Medicine and Therapeutics
  • Member and past Director, Institute of Digestive Disease

Expertise

  • Gastroenterology and Hepatology

Education and Qualifications

MBChB (CUHK), MD (CUHK), FRCP (Edin), FRCP (Lond), FHKCP, FHKAM (Med), FAASLD

Research Interests

  • Viral hepatitis
  • Liver fibrosis
  • Liver cancer
  • Anti-viral therapy
  • Fatty liver disease

Additional Information

Award & Honour
  • Highly Cited Researcher (Cross Field), Clarivate Analytics, 2018
  • Guangdong Province Science & Technology Award - First-class Award, 2018
  • Okuda Lectureship Award, Asia Pacific Digestive Week, 2018
  • Chainuvati Lecturer, Thai Association for the Study of the Liver, Thailand, 2018
  • Excellent Research Award, Food and Health Bureau, Hong Kong, 2014
  • National Award for Science and Technology Progress 2012 - Second-class, 2012
  • MoE Higher Education Outstanding Scientific Research Output Award (Scientific and Technological Progress Award) - First-class, Ministry of Education, 2012
  • Sir David Todd Lectureship, Hong Kong College of Physicians, 2011
  • Croucher Senior Medical Research Fellowship, The Croucher Foundation, Hong Kong, 2011
  • JGH Emerging Leader Lectureship Award, Asia Pacific Digestive Week, 2010
  • Excellent Research Award (Clinical Studies), Food and Health Bureau, Hong Kong, 2010
  • Association of Southeast Asian Institutions of Higher Learning -Scopus Young Scientist Award, 2008
  • Distinguished Research Paper Award for Young Investigators, Hong Kong College of Physicians, 2008
  • Young Investigator Award, Asian Pacific Association for the Study of the Liver, 2008
  • Ten Outstanding Young Persons Award, Hong Kong, 2008
Professional Service
  • Chairman, Strategic Technical Advisory Committee for Viral Hepatitis, Western Pacific Regional Office of World Health Organization
  • Global council member, International Association for the Study of the Liver
  • Council member and past president, Hong Kong Association for the Study of Liver Diseases
  • Deputy Chief of Service, Department of Medicine and Therapeutics, Prince of Wales Hospital
  • Associate editor, Hepatology International
  • Associate editor, Seminar of Liver Diseases
Academic Engagement in CUHK
  • Programme Director, Certificate in Professional Medical Communication
  • Associate Programme Director, Master of Science in Gastroenterology
  • Supervisor, MPhil and PhD in Medical Sciences
  • Lecturer, Diploma in Advances in Medicine

Research and Publications

  1. VWS Wong, GLH Wong, RS Chan, SST Shu, BH Cheung, LS Li, AML Chim, CK Chan, JK Leung, WCW Chu, J Woo, HLY Chan. Beneficial effects of lifestyle intervention in non-obese patients with non-alcoholic fatty liver disease. J Hepatol 2018;69:1349-56.
  2. K Agarwal, M Brunetto, WK Seto, YS Lim, S Fung, P Marcellin, SH Ahn, N Izumi, WL Chuang, H Bae, M Sharma, HLA Janssen, CQ Pan, M Celen, N Furusyo, Shalimar, KT Yoon, H Trinh, JF Flaherty, A Gaggar, A Lau, AL Cathcart, L Lin, N Bhardwaj, V Suri, GM Subramanian, E Gane, M Buti, HLY Chan. 96 weeks treatment of tenofovir alafenamide versus tenofovir disoproxil fumarate for the treatment of chronic hepatitis B virus infection. J Hepatol 2018;68:672-81.
  3. TCF Yip, GLH Wong, VWS Wong, YK Tse, GCY Lui, KLY Lam, HLY Chan. Durability of hepatitis B surface antigen seroclearance in untreated and nucleos(t)ide analogue-treated patients. J Hepatol 2018;68:63-72.
  4. HLY Chan, S Fung, WK Seto, WL Chuang, CY Chen, HJ Kim, AJ Hui, HLA Janssen, A chowdhury, TY Tsang, R Mehta, E Gane, JF Flaherty, B Massetto, A Gaggar, KM Kitrinos, L Lin, GM Subramanian, JG McHutchison, YS Lim, SK Acharya, K Agarwal, GS-US-320-0110 investigators. Tenofovir alafenamide versus tenofovir disoproxil fumarate for the treatment of HBeAg-positive chronic hepatitis B virus infection: a randomized, double-blind, phase 3, non-inferiority trial. Lancet Gastroenterol Hepatol 2016;1:185-95.
  5. HLY Chan, SH Ahn, TT Chang, CY Peng, D Wong, CS Coffin, SG Lim, PJ Chen, HLA Janssen, P Marcellin, L Serfaty, S Zeuzem, D Cohen, L Critelli, D Xu, M Wind-Rotolo, E Cooney, and the LIRA-B study team. Peginterferon lambda for the treatment of HBeAg-positive chronic hepatitis: a randomized phase 2b study (LIRA-B). J Hepatol 2016;64:1011-9.
  6. VWS Wong, GLH Wong, JCL Yeung, CYK Fung, JKL Chan, ZHY Chang, CTY Kwan, HW Lam, J Limquiaco, AML Chim, HLY Chan. Long-term clinical outcomes after fatty liver screening in patients undergoing coronary angiogram: a prospective cohort study. Hepatology 2016;63:754-63.
  7. P Marcellin, SH Ahn, X Ma, FA Caruntu, WY Tak, M Elkashab, WL Chuang, SG Lim, F Tabak, R Mehta, J Petersen, GR Foster, L Lou, EB Martins, P Dinh, A Corsa, P Charuworn, GM Subramanian, H Reiser, HW Reesink, S Fung, SI Strasser, H Trinh, M Buti, GB Gaeta, AJ Hui, G Papatheodoridis, R Flisiak, HLY Chan, on behalf of the study 149 investigators. Combination of tenofovir disoproxil fumarate and peginterferon alfa-2a increases loss of hepatitis B surface antigen in patients with chronic hepatitis B. Gastroenterology 2016;150:134-44.
  8. Y Tian, VWS Wong, GLH Wong, W Yang, H Sun, J Shen, JH Tong, MY Go, YS Cheung, PB Lai, M Zhou, G Xu, YH Huang, J Yu, KF To, ASF Cheng, HLY Chan. Histone deacetylase HDAC8 promotes insulin resistance and β-catenin activation in NAFLD-associated hepatocellular carcinoma. Cancer Res 2015;75:4803-16.
  9. VWS Wong, GLH Wong, DKW Yeung, TKT Lau, CKM Chan, AML Chim, JM Abrigo, RSM Chan, J Woo, YK Tse, WCW Chu, HLY Chan. Incidence of non-alcoholic fatty liver disease in Hong Kong: a population study with paired proton-magnetic resonance spectroscopy. J Hepatol 2015;62:182-9.
  10. HLY Chan, CK Chan, AJ Hui, S Chan, F Poordad, TT Chang, P Mathurin, JF Flaherty, L Lin, A Corsa, A Gaggar, GM Subramanian, JG McHutchison, S Lee, EJ Gane. Effects of tenofovir disoproxil fumarate in hepatitis B e antigen-positive patients with normal levels of alanine aminotransferase and high levels of hepatitis B virus DNA. Gastroenterology 2014;146:1240-8.

Prof Henry L.Y. CHAN

Honorary Professor

Division of Gastroenterology and Hepatology
Department of Medicine and Therapeutics

Prof Winnie C.W. CHU

Department of Imaging and Interventional Radiology

Contact Information
Tel: (852) 3505 2299
Email: winniechu@cuhk.edu.hk

 

CUHK Employment

  • Professor, Department of Imaging and Interventional Radiology

Honorary appointments

  • Founding member & Secretary of Asian Oceanic Society of Paediatric Radiology (AOSPR)
  • Secretary & board member of International Research Society of Spinal Deformities (IRSSD)
  • Editor of Hong Kong Journal of Radiology (HKJR)
  • Editorial board member for Pediatric Radiology and Scoliosis

Education and Qualifications

  • MBChB, MD, CUHK
  • Fellowship of the Royal College of Radiology, FRCR
  • Fellowship of the Hong Kong Academy of Medicine (Radiology), FHKAM (Radiology)

Research Interests

  • Imaging in adolescent idiopathic scoliosis
  • Imaging of paediatric oncology and haematological diseases
  • Urinary tract imaging in paediatrics
  • Ultrasound imaging
  • Functional MRI imaging in neurocognitive disease
  • Advanced computer analysis in medical imaging

Prof Winnie C.W. CHU

Professor

Department of Imaging and Interventional Radiology

Prof Paul B.S. LAI

Division of Hepato-Biliary and Pancreatic Surgery, Department of Surgery

Contact Information
Tel: (852) 3505 1496
Email: paullai@cuhk.edu.hk

 

CUHK Employment

  • Professor and Division Chief, Division of Hepato-biliary and Pancreatic Surgery, Department of Surgery
  • Director of the Wong Tze Lam - Hing Tak Centre of Surgical Outcome Research
  • Director, Office of Medical Education, Faculty of Medicine
  • Professor (by courtesy), of the School of Biomedical Sciences

Honorary appointments

  • Honorary Consultant HBP Surgeon, Department of Surgery, Prince of Wales Hospital

Expertise

-

Education and Qualifications

MBChB(CUHK), MD(CUHK), FCSHK, FHKAM(Surgery), FRCSEd (Gen), FRCS(Glas), FRACMA, FHKCCM

Research Interests

  • Clinical research in general surgery and hepato-biliary and pancreatic surgery
  • Molecular genetics of liver cancer and other cancers
  • Hospital administration, quality and risk management
  • Surgical outcome research
  • Medico-legal study and mediation
  • Medical education research

Additional Information

Professional Service
  • Head of Cluster HBP Surgery Services, New Territories East Cluster, Hospital Authority
  • Director, Surgical Outcomes Monitoring & Improvement Program (SOMIP), Hospital Authority Head Office
  • Immediate Past President (since September 2019), College of Surgeons of Hong Kong and the Hong Kong Academy of Medicine
  • Editor-in-chief of Surgical Practice (the official journal for the College of Surgeons of Hong Kong)
  • Deputy Chairman, Education Committee, Hong Kong Academy of Medicine (since October 2019)

Prof Paul B.S. LAI

Professor

Division of Hepato-Biliary and Pancreatic Surgery
Department of Surgery

Prof James Y.W. LAU

Division of Vascular Surgery, Department of Surgery

Contact Information
Tel: (852) 3505 1411
Email: laujyw@surgery.cuhk.edu.hk

 

CUHK Employment

  • Chairman, Department of Surgery
  • Yao Ling Sun Professor of Surgery
  • Head, Division of Surgery, Graduate School

Honorary appointments

  • Honorary Director, Endoscopy Centre, New Territories East Cluster, Hospital Authority
  • Honorary Consultant Surgeon, New Territories East Cluster, Hospital Authority

Expertise

  • Therapeutic Endoscopy, Vascular Surgery

Education and Qualifications

MBBS (Hons) (UNSW), MD (CUHK), FRCS (Edin), FCSHK, FHKAM, FRCS (Glasg)

Research Interests

  • Peptic ulcer bleeding, endoscopic therapy

Research and Publications

  1. Sung JJ, Luo D, Wu JC, Ching JY, Chan FK, Lau JY, Mack S, Ducharme R, Okolo P,
    Canto M, Kalloo A, Giday SA. Early clinical experience of the safety and
    effectiveness of Hemospray in achieving hemostasis in patients with acute peptic
    ulcer bleeding. Endoscopy. 2011 Apr;43(4):291-5. doi: 10.1055/s-0030-1256311.
    Epub 2011 Mar 31. PubMed PMID: 21455870.
  2. Pang SH, Ching JY, Lau JY, Sung JJ, Graham DY, Chan FK. Comparing the
    Blatchford and pre-endoscopic Rockall score in predicting the need for endoscopic
    therapy in patients with upper GI hemorrhage. Gastrointest Endosc. 2010
    Jun;71(7):1134-40. doi: 10.1016/j.gie.2010.01.028. PubMed PMID: 20598244.
  3. Lau J, Sung JJ. From endoscopic hemostasis to bleeding peptic ulcers:
    strategies to prevent and treat recurrent bleeding. Gastroenterology. 2010
    Apr;138(4):1252-4, 1254.e1. doi: 10.1053/j.gastro.2010.02.017. Epub 2010 Feb 18.
    PubMed PMID: 20171965.
  4. Sung JJ, Lau JY, Ching JY, Wu JC, Lee YT, Chiu PW, Leung VK, Wong VW, Chan FK.
    Continuation of low-dose aspirin therapy in peptic ulcer bleeding: a randomized
    trial. Ann Intern Med. 2010 Jan 5;152(1):1-9. doi:
    10.7326/0003-4819-152-1-201001050-00179. Epub 2009 Nov 30. PubMed PMID: 19949136.
  5. Sung JJ, Barkun A, Kuipers EJ, Mössner J, Jensen DM, Stuart R, Lau JY, Ahlbom
    H, Kilhamn J, Lind T; Peptic Ulcer Bleed Study Group. Intravenous esomeprazole
    for prevention of recurrent peptic ulcer bleeding: a randomized trial. Ann Intern
    Med. 2009 Apr 7;150(7):455-64. Epub 2009 Feb 16. PubMed PMID: 19221370.
  6. Lau JY, Sung JJ, Lee KK, Yung MY, Wong SK, Wu JC, Chan FK, Ng EK, You JH, Lee
    CW, Chan AC, Chung SC. Effect of intravenous omeprazole on recurrent bleeding
    after endoscopic treatment of bleeding peptic ulcers. N Engl J Med. 2000 Aug
    3;343(5):310-6. PubMed PMID: 10922420.
  7. Lau JY, Sung JJ, Lam YH, Chan AC, Ng EK, Lee DW, Chan FK, Suen RC, Chung SC.
    Endoscopic retreatment compared with surgery in patients with recurrent bleeding
    after initial endoscopic control of bleeding ulcers. N Engl J Med. 1999 Mar
    11;340(10):751-6. PubMed PMID: 10072409.
  8. Lau JY, Chung SC, Leung JW, Lo KK, Yung MY, Li AK. The evolution of stigmata
    of hemorrhage in bleeding peptic ulcers: a sequential endoscopic study.
    Endoscopy. 1998 Aug;30(6):513-8. PubMed PMID: 9746158.
  9. Lau JY, Sung JJ, Chan AC, Lai GW, Lau JT, Ng EK, Chung SC, Li AK. Stigmata of
    hemorrhage in bleeding peptic ulcers: an interobserver agreement study among
    international experts. Gastrointest Endosc. 1997 Jul;46(1):33-6. PubMed PMID:
    9260702.
  10. Chung SS, Lau JY, Sung JJ, Chan AC, Lai CW, Ng EK, Chan FK, Yung MY, Li AK.
    Randomised comparison between adrenaline injection alone and adrenaline injection
    plus heat probe treatment for actively bleeding ulcers. BMJ. 1997 May
    3;314(7090):1307-11. PubMed PMID: 9158465; PubMed Central PMCID: PMC2126544.

Prof James Y.W. LAU

Professor

Division of Vascular Surgery
Department of Surgery

Prof Brigette B.Y. MA

Department of Clinical Oncology

Contact Information
Tel: (852) 3505 2118
Email: brigette@clo.cuhk.edu.hk

 

CUHK Employment

  • Professor (Clinical), Department of Clinical Oncology
  • Medical Director, Phase 1 Clinical Trial Centre
  • Co-director of the Cancer Drug Testing Unit, Department of Clinical Oncology

Honorary appointments

  • Honorary Consultant, Hong Kong Hospital Authority
  • Honorary Professor, Department of Health Technology and Informatics, The Hong Kong Polytechnic University

Education and Qualifications

  • Doctor of Medicine, The Chinese University of Hong Kong
  • Fellow of the Hong Kong Academy of Medicine
  • Fellow of the Hong Kong College of Physicians (Medical Oncology)
  • Fellow of the Royal Australasian College of Physician (Internal Medicine, Medical Oncology)
  • Bachelor of Medicine and Bachelor of Surgery

Research Interests

  • Cancer drug development: preclinical and clinical
  • Immunotherapy
  • Nasopharyngeal cancer
  • Translational research and cancer biomarker
  • Colorectal and related cancers
  • Precision Oncology

Research and Publications

  1. Ma B, King AD, Leung L, Wang K, Poon A, Ho WM, Mo F, Chan CML, Chan ATC, Wong SCS. Identifying an early indicator of drug efficacy in patients with metastatic colorectal cancer - a prospective evaluation of circulating tumor cells, 18F-fluorodeoxyglucose positron-emission tomography and the RECIST criteria. Ann Oncol. 2017; 28(7):1576-81.
  2. Li YY, Chung GT, Lui VW, TO KF, Ma BB, Chow C, Woo JK, Yip KY, Seo JS, Hui EP, Mak MK, Rusan M, Chau NG, Or YY, Law MH, Law PP, Liu ZW, Ngan HL, Hau PM, Verhoeft KR, Poon PH, Yoo SK, Shin JY, Lee SD, Lun SW, Jia L, Chan AW, Chan JY, Lai PB, Fung CY, Hung ST, Wang L, Chang AM, Chiosea SI, Hedberg ML, Tsao SW, van Hasselt AC, Chan AT, Grandis JR, Hammerman PS, Lo KW*. Exome and genome sequencing of nasopharynx cancer identifies NF-KB pathway activating mutations. Nat Commun. 2017 Jan 18; 8:14121.
  3. Chan KCA, Woo JKS, King A, Zee B, Lam JWK, Chan SL, Chu SW, Mak C, Tse I, Leung S, Chan G, Hui EP, Ma BBY, Chiu RWK, Leung SF, Van Hasselt A, Chan ATC, Lo YMD. Analysis of Plasma Epstein–Barr Virus DNA to Screen for Nasopharyngeal Cancer. N Engl J Med. 2017; 377:513-22.
  4. Van Cutsem E, Cervantes A, Adam R, Sobrero A, Van Krieken JH, Aderka D, Aranda Aguilar E, Bardelli A, Benson A, Bodoky G, Ciardiello F, D'Hoore A, Diaz-Rubio E, Douillard JY, Ducreux M, Falcone A, Grothey A, Gruenberger T, Haustermans K, Heinemann V, Hoff P, Köhne CH, Labianca R, Laurent-Puig P, Ma B, Maughan T, Muro K, Normanno N, Österlund P, Oyen WJ, Papamichael D, Pentheroudakis G, Pfeiffer P, Price TJ, Punt C, Ricke J, Roth A, Salazar R, Scheithauer W, Schmoll HJ, Tabernero J, Taïeb J, Tejpar S, Wasan H, Yoshino T, Zaanan A, Arnold DArnold. European Society of Medical Oncology Consensus Guidelines for the management of patients with metastatic colorectal cancer – 2016. Ann Oncol 2016; 27(8):1386-422.
  5. Li J, Qin SK, Xu R, Yau T, Ma BBY, Pan H, Xu J, Bai Y, Chi Y, Wang L, Yeh KH, Bi F, Cheng Y, Le AT, Lin JK, Liu T, Ma D, Kappeler C, Kalmus J, Kim TW, on behalf of the CONCUR Investigators. Regorafenib monotherapy in Asian patients with previously treated metastatic colorectal cancer (CONCUR): a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet Oncol. 2015; 16(6):619-29.
  6. Lee A, Ma B, Ng WT, Chan ATC. The management of nasopharyngeal carcinoma – current practice and future perspective. J Clin Oncol. 2015; 33(29):3356-64.
  7. Ma B, Chan L, Ho WM, Lau W, Mo F, Hui EP, Chan C, Poon A, Dattatray R, Wong C, KF To, King AD, Ahuja A, Chan ATC. Intermittent versus continuous erlotinib with concomitant modified ‘Xelox’ (q3W) in first-line treatment of metastatic colorectal cancer - correlation with serum amphiregulin and transforming growth factor receptor alpha. Cancer 2013; 119:4145-53.
  8. Ma BBY, EP Hui, TSK Mok. Population-based differences in treatment outcome following anti-cancer drug therapies. Lancet Oncol. 2010; 11(1):75-84.
  9. Ma BBY, EP Hui, SCC Wong, SY Tung, KK Yuen, A King, SL Chan, SF Leung, MK Kam, BKH Yu, B Zee, ATC Chan. Multicenter phase II study of gemcitabine and oxaliplatin in advanced nasopharyngeal carcinoma - correlation with excision repair cross complementing-1 polymorphisms. Ann Oncol. 2009; 20 (11):1854-9.
  10. Ma B, Bristow R, Kim J, Siu L. Combined-modality treatment of solid tumors using radiotherapy and molecular targeted agents. J Clin Oncol 2003; 21(14)2760-76.

Prof Brigette B.Y. MA

Professor

Department of Clinical Oncology

Prof Siew C. NG

Division of Gastroenterology and Hepatology, Department of Medicine and Therapeutics

Contact Information
Tel: (852) 3505 3996
Email: siewchienng@cuhk.edu.hk

CUHK Employment

  • Professor, Institute of Digestive Disease
  • Professor, Department of Medicine and Therapeutics
  • Professor, State Key Laboratory of Digestive Disease (CUHK)
  • Associate Director, Centre for Gut Microbiota Research
  • Assistant Dean (Development), Faculty of Medicine
  • Director, Microbiota Innovation Center (M@gIC), Health@InnoHK

Honorary appointments

  • Honorary Consultant, Prince of Wales Hospital, Hong Kong
  • Honorary Senior Clinical Fellow, University of Melbourne, Australia
  • Visiting Professor, Shanghai Medical College, Fudan University, China

Expertise

  • Inflammatory Bowel Disease
  • Fecal Microbiota Transplantation
  • Colorectal Cancer
  • Endoscopy

Education and Qualifications

MBBS (Lond), PhD (Lond), FRCP (Lond), FRCP (Edin), FHKCP, FHKAM (Medicine), AGAF

Research Interests

  • Epidemiology, genetics, pathogenesis, and treatment of IBD
  • Role of Gut microbiota in health and disease
  • Fecal microbiota transplantation and microbial therapeutics

Additional Information

Award & Honour
  • 14th Joanna and David B. Sachar M.D International Award and Visiting Professorship in Inflammatory Bowel Diseases in Inflammatory Bowel Diseases, Icahn School of Medicine at Mount Sinai, 2019
  • Visiting Professor, Shanghai Medical College, Fudan University, China
  • Sir David Todd Lectureship, Hong Kong College of Physicians, 2017
  • Outstanding Fellow, Faculty of Medicine, The Chinese University of Hong Kong, 2017
  • Research Excellence Award, The Chinese University of Hong Kong, 2016
  • AGA Young Investigator Award, Digestive Disease Week (DDW), 2016
  • Distinguished Research Paper Award for Young Investigators, Hong Kong College of Physicians, 2014 – 2016
  • Medicine 3-Exemplary Teaching Award, Faculty of Medicine, The Chinese University of Hong Kong, 2014-2016
  • JGH Emerging Leader Lectureship Award, Asian-Pacific Association of Gastroenterology, 2014
  • Higher Education Outstanding Scientific Research Output Award – First-class Award in Natural Sciences, Ministry of Education, 2014
  • Young Researcher Award, The Chinese University of Hong Kong, 2013
  • Hong Kong Society of Gastroenterology Research Project Award 2013
  • Gold Medal for Best Thesis Award, Hong Kong College of Physicians, 2014
  • Best Presenter for Distinguished Research Paper Award for Young Investigators, Hong Kong College of Physicians, 2014
Professional Service
  • Associate Editor, Gut
  • External Assessor, University of Malaya
Academic Engagement in CUHK
  • Mentor, MBChB Programme Global Physician-Leadership Stream (GPS)

Research and Publications

  1. T Zuo, SH Wong, CP Cheung, K Lam, R Lui, K Cheung, F Zhang, W Tang, JYL Ching, JCY Wu, PKS Chan, JJY Sung, J Yu, FKL Chan, and SC Ng, Gut fungal dysbiosis correlates with reduced efficacy of fecal microbiota transplantation in Clostridium difficile infection. Nature Communications, 09, 2018. 9(1): p. 3663.
  2. T Zuo, MA Kamm, JF Colombel, SC Ng, Urbanization and the Gut Microbiota in Health and Inflammatory. Nature Reviews Gastroenterology & Hepatology. 07, 2018. 15(7): p. 440-452.
  3. SC Ng, HY Shi, N Hamidi , et al. Worldwide Incidence and Prevalence of Inflammatory Bowel Disease in the 21st Century: a Systematic Review of Population-based Studies. Lancet. 12, 2017. 390(10114): p. 2769-2778.
  4. T Zuo, SH Wong, SC Ng, et al. Bacteriophage Transfer During Faecal Microbiota Transplantation in Clostridium Difficile Infection Is Associated with Treatment Outcome. Gut. 04, 2017. 67(4): p. 634-643.
  5. GG Kaplan and SC Ng, Understanding and Preventing the Global Increase of Inflammatory Bowel Disease. Gastroenterology. 02, 2017. 152: p. 313-321.e312.
  6. SC Ng, JYW Lau, FKL Chan, et al. Risk of Advanced Adenomas in Siblings of Individuals with Advanced Adenomas: A Cross-Sectional Study. Gastroenterology. 03, 2016. 150: p. 608-616.
  7. JZ Liu, S Van Sommeren, H Huang, SC Ng, et al. Association Analyses Identify 38 Susceptibility Loci for Inflammatory Bowel Disease and Highlight Shared Genetic Risk across Populations. Nature Genetics. 08, 2015. 47: p. 979-986.
  8. SC Ng, W Tang, RW Leong, et al. Environmental Risk Factors in Inflammatory Bowel Disease: A Population-Based Case-Control Study in Asia-Pacific. Gut. 07, 2015. 64: p. 1063-1071.
  9. SC Ng, W Tang, JY Ching, et al. Incidence and Phenotype of Inflammatory Bowel Disease Based on Results from the Asia-Pacific Crohn's and Colitis Epidemiology Study. Gastroenterology. 07, 2013.
  10. SC Ng, JYW Lau, FKL Chan, et al. Increased Risk of Advanced Neoplasms among Asymptomatic Siblings of Patients with Colorectal Cancer. Gastroenterology. 03, 2013. 144: p. 544-550.

Prof Siew C. NG

Professor

Division of Gastroenterology and Hepatology
Department of Medicine and Therapeutics

Prof Simon S.N. NG

Division of Colorectal Surgery, Department of Surgery

Contact Information
Tel: (852) 3505 1495
Email: simonng@surgery.cuhk.edu.hk

 

CUHK Employment

  • Associate Dean (Student Affairs), Faculty of Medicine
  • Director, Global Physician-Leadership Stream (GPS), MBChB Programme
  • Professor, Department of Surgery
  • Professor (by courtesy), School of Biomedical Sciences
  • Assembly of Fellows, S.H. Ho College

Expertise

  • Colorectal surgery
  • Laparoscopic and robotic surgery
  • Endoscopy

Education and Qualifications

MBChB(Hons)(CUHK), MD(CUHK), FRCS(Edin), FCSHK, FRCSEd(Gen), FHKAM(Surgery)

Research Interests

  • Minimally invasive and robotic surgery for colorectal diseases
  • Advanced endoscopic therapy for colorectal diseases
  • Multimodality treatment for colorectal cancer
  • Colorectal cancer screening
  • Molecular biomarkers for colorectal cancer
  • Integrative medicine

Additional Information

Award & Honour
  • Outstanding Fellowship, Faculty of Medicine, CUHK, 2019
  • Positive Workplace Service Award, CUHK, 2018-2019
  • Teacher of the Year Awards, Faculty of Medicine, CUHK, 2005-06, 2006-07, 2007-08, 2008-09, 2009-10, 2017, 2018, 2019
  • State Natural Science Award – Second-class Award, 2016
  • Royal College of Surgeons of Edinburgh China Medal, 2014 & 2016
  • British Journal of Surgery Prize, The European Society of Coloproctology, 2011 & 2014
  • Ministry of Education Higher Education Outstanding Scientific Research Output Award – First-class Award in Natural Sciences, 2014
  • Certificate of Merit for Doctor of Medicine Thesis, CUHK, 2013
  • Fellowship of the American College of Surgeons, FACS, 2011
  • GB Ong Travelling Fellowship, 2011
  • International Guest Scholar, The American College of Surgeons, 2010
  • Ten Outstanding Young Persons of Hong Kong, 2010
  • Master Teacher Award, Faculty of Medicine, CUHK, 2010
  • Northern California Society of Colon and Rectal Surgeons Award, The American Society of Colon and Rectal Surgeons, 2008
  • Li-Shields’ Medal, 2002
  • City Lions Club Gold Medal, 1995
  • Dr. R. C. Lee Memorial Gold Medal in Surgery, 1995
Professional Service
  • President, Hong Kong Society for Coloproctology
  • Chairman, CME & CPD Committee, College of Surgeons of Hong Kong
  • Member, Colorectal Cancer Screening Pilot Programme Task Force, Department of Health
  • Member, Grant Review Board, Food and Health Bureau
  • Member, New Territories Regional Advisory Committee, Hospital Authority

Research and Publications

  1. Ng SS, Lee JF, Yiu RY, Li JC, Hon SS, Mak TW, Leung WW, Leung KL. Long-Term Oncologic Outcomes of Laparoscopic Versus Open Surgery for Rectal Cancer: A Pooled Analysis of 3 Randomized Controlled Trials. Ann Surg 2014; 259: 139-147.
  2. Ng SS, Lee JF, Yiu RY, Li JC, Hon SS, Mak TW, Ngo DK, Leung WW, Leung KL. Laparoscopic-assisted versus open total mesorectal excision with anal sphincter preservation for mid and low rectal cancer: a prospective randomized trial. Surg Endosc 2014; 28: 297-306.
  3. Ng SS, Leung WW, Mak TW, Hon SS, Li JC, Wong CY, Tsoi KK, Lee JF. Electroacupuncture Reduces Duration of Postoperative Ileus After Laparoscopic Surgery for Colorectal Cancer. Gastroenterology 2013; 144: 307-313.
  4. Wu CW, Ng SS, Dong Y, Ng SC, Leung WW, Lee CW, Wong YN, Chan FK, Yu J, Sung JJ. Detection of miR-92a and miR-21 in stool samples as potential screening biomarkers for colorectal cancer and polyps. Gut 2012; 61: 739-745.
  5. Ng EK, Chong WW, Jin H, Lam EK, Shin VY, Yu J, Poon TC, Ng SS, Sung JJ. Differential expression of microRNAs in plasma of colorectal cancer patients: A potential marker for colorectal cancer screening. Gut 2009; 58: 1375-1381.
  6. Ng SS, Leung KL, Lee JF, Yiu RY, Li JC, Hon SS. Long-term morbidity and oncologic outcomes of laparoscopic-assisted anterior resection for upper rectal cancer: ten-year results of a prospective, randomized trial. Dis Colon Rectum 2009; 52: 558-566.
  7. Ng SS, Leung KL, Lee JF, Yiu RY, Li JC, Teoh AY, Leung WW. Laparoscopic-assisted versus open abdominoperineal resection for low rectal cancer: a prospective randomized trial. Ann Surg Oncol 2008; 15: 2418-2425.
  8. Ng SS, Li JC, Lee JF, Yiu RY, Leung KL. Laparoscopic total colectomy for colorectal cancers: a comparative study. Surg Endosc 2006; 20: 1193-1196.
  9. Ng SS, Leung KL, Lee JF, Yiu RY, Li JC. MRC CLASICC trial. Lancet 2005; 366: 713.
  10. Leung KL, Kwok SP, Lam SC, Lee JF, Yiu RY, Ng SS, Lai PB, Lau WY. Laparoscopic resection of rectosigmoid carcinoma: prospective randomised trial. Lancet 2004; 363: 1187-1192.

Prof Simon S.N. NG

Professor

Division of Colorectal Surgery
Department of Surgery

Prof Ka Fai TO

Department of Anatomical and Cellular Pathology

Contact Information
Tel: (852) 3505 3335
Email: kfto@cuhk.edu.hk

 

CUHK Employment

  • Professor and Chairman, Department of Anatomical and Cellular Pathology

Expertise

  • Histopathology

Education and Qualifications

MBChB (CUHK), FRCPA, FHKCPath, FHKAM(Path)

Research Interests

  • Common Asian Cancers
  • Cancer Molecular Diagnostics
  • Gastrointestinal Tract Pathology

Additional Information

Professional Service
  • Honorary Chief of Service, Anatomical & Cellular Pathology Department, Prince of Wales Hospital (PWH), HKSAR
  • Associate Director, State Key Laboratory in Oncology in South China (HKSAR)
  • Core Member of Institute of Digestive Disease (IDD), CUHK
  • Pathology Committee Member of International Association for the Study of Lung Cancer (IASLC)

Research and Publications

  1. Lo KW, Chung GT, To KF. Deciphering the molecular genetic basis of NPC through molecular, cytogenetic, and epigenetic approaches. Semin Cancer Biol. 2012 Apr;22(2):79-86.
  2. Kang W, Tong JH, Chan AW, Lee TL, Lung RW, Leung PP, So KK, Wu K, Fan D, Yu J, Sung JJ, To KF. Yes-associated protein 1 exhibits oncogenic property in gastric cancer and its nuclear accumulation associates with poor prognosis. Clin Cancer Res. 2011 Apr 15;17(8):2130-9.
  3. Lung RW, Tong JH, Sung YM, Leung PS, Ng DC, Chau SL, Chan AW, Ng EK, Lo KW, To KF. Modulation of LMP2A expression by a newly identified Epstein-Barr virus-encoded microRNA miR-BART22. Neoplasia . 2009 Nov;11(11):1174-84.
  4. Lo AK, To KF, Lo KW, Lung RW, Hui JW, Liao G, Hayward SD. Modulation of LMP1 protein expression by EBV-encoded microRNAs. Proc Natl Acad Sci U S A . 2007 Oct 9;104(41):16164-9.
  5. Ng WF, To KF. Pathology of human H5N1 infection: new findings. Lancet. 2007 Sep 29;370(9593):1106-8. Commentary.
  6. Lo AW, Tang NL, To KF. How the SARS coronavirus causes disease: host or organism? J Pathol. 2006 Jan;208(2):142-51. Review.
  7. To KF, Tong JHM, Chan PKS, Au FWL, Chim SSC, Chan KCA, Cheung JLK, Liu EYM, Tse GMK, Lo AWI, Lo YMD, Ng HK. Tissue and cellular tropisms of the coronavirus associated with Severe Acute Respiratory Syndrome – an in-situ hybridization study of fatal cases. J Pathol. 2004 Feb;202(2):157-63.
  8. Lo KW, To KF, Huang DP. Focus on nasopharyngeal carcinoma. Cancer Cell. 2004;5:423-8.
  9. Lee TL, Leung WK, Chan MWY, Ng EKW, Tong JHM, Lo KW, Chung SCS, Sung JJY, To KF . Detection of gene promoter hypermethylation in the tumor and serum of patients with gastric carcinoma. Clin Cancer Res. 2002;8:1761-6.
  10. Chan FKL, To KF, Wu JCY, Yung MY, Leung WK, Kwok T, Hui Y, Chan HLY, Chan CSY, Hui E, Woo J, Sung JJY. Eradication of Helicobacter pylori and risk of peptic ulcers in patients starting long-term treatment with non-steroidal anti-inflammatory drugs: a randomized trial. Lancet 2002 359(9300):9-13.

Prof Ka Fai TO

Professor

Department of Anatomical and Cellular Pathology

Prof Grace L.H. WONG

Division of Gastroenterology and Hepatology, Department of Medicine and Therapeutics

Contact Information
Tel: (852) 3505 3125
Email: wonglaihung@cuhk.edu.hk

CUHK Employment

  • Professor, Institute of Digestive Disease
  • Professor, Department of Medicine and Therapeutics
  • Professor, State Key Laboratory of Digestive Diseases (CUHK)
  • Assistant Dean (Learning Experience), Faculty of Medicine

Honorary appointments

  • (from IDD old website)
  • Honorary Consultant, Prince of Wales Hospital
  • Honorary Consultant, Center for Liver Health, The Chinese University of Hong Kong

Expertise

  • Gastroenterology and Hepatology
  • Hepatitis
  • Liver Cancer
  • Liver Fibrosis
  • Peptic Ulcer
  • Big Data in Medicine

Education and Qualifications

MBChB (CUHK), MD (CUHK), FRCP (Lond, Edin), FHKCP, FHKAM (Medicine)

Research Interests

  • Viral Hepatitis
  • Hepatocelluar Carcinoma
  • Non-Invasive Assessment Of Liver Fibrosis
  • Idiopathic Peptic Ulcer
  • Big Data In Medicine

Additional Information

Award & Honour
  • Presidential Plenary Award, Asian-Pacific Association for the Study of the Live 2019
  • Guangdong Province Science & Technology First Class Award, 2018
  • JGHF Emerging Leader Lectureship, JGH Foundation, 2017
  • Sir David Todd Lectureship, Hong Kong College of Physicians, 2016
  • Distinguished Research Paper Award for Young Investigators, Hong Kong College of Physicians, 2010, 2013, 2014, 2015
  • Ten Outstanding Young Persons Award, Hong Kong, 2014
  • Travel Grant Award, School of Research Methodology, the 22nd Conference of the Asian-Pacific Association for the Study of the Liver, 2012
  • Young Investigator Award: Asian Pacific Association for the Study of the Liver, Hong Kong, 2009
  • Bronze Award, Best Original Research by Trainees: Hong Kong Academy of Medicine, 2008
Professional Service
  • Honorary Treasurer, The Hong Kong Association for the Study of Liver Diseases
  • Editor-in-Chief, Hepatology (Hong Kong Edition)
  • Associate Editor, Alimentary Pharmacology and Therapeutics
Academic Engagement in CUHK
  • Director, Master of Science Programme in Gastroenterology
  • Coordinator, Summer Clinical Attachment Programme (SCAP), Department of Medicine and Therapeutics

Research and Publications

  1. Wong GL, Wong VW, Chan HL. Towards finite oral antiviral treatment for chronic hepatitis B. Lancet Gastroenterol Hepatol. 2019 Apr;4(4):260-262.
  2. Wong GL, Lau LH, Ching JY, et al. Prevention of recurrent idiopathic gastroduodenal ulcer bleeding: a double-blind, randomised trial. Gut 2019 Jun. [Epub ahead of print]
  3. Wong GL, Liang LY, Kwok R, et al. Low risk of variceal bleeding in cirrhotic patients after variceal screening stratified by liver/spleen stiffness. Hepatology 2019 Sep;70(3):971-981.
  4. Wong GL, Ma AJ, Deng H, et al. Machine learning model to predict recurrent ulcer bleeding in patients with history of idiopathic gastroduodenal ulcer bleeding. Aliment Pharmacol Ther 2019 Apr;49(7):912-918.
  5. Wong GL, Chan HL, Tse YK, et al. Normal on-treatment ALT during antiviral treatment is associated with a lower risk of hepatic events in patients with chronic hepatitis B. J Hepatol 2018;69(4):793-802.
  6. Wong GL, Wong VW. Eliminating hepatitis B virus as a global health threat. Lancet Infect Dis. 2016 Dec;16(12):1313-1314.
  7. Wong GL, Tse YK, Wong VW, et al. Long-term safety of oral nucleos(t)ide analogues for patients with chronic hepatitis B - a cohort study of 53,500 subjects. Hepatology 2015;62:684-93.
  8. Wong GL, Chan HL, et al. On-treatment alpha-fetoprotein is a specific tumor marker for hepatocellular carcinoma in patients with chronic hepatitis B receiving entecavir. Hepatology 2014;59:986-95.
  9. Wong GL, Chan HL, Chan HY, et al. Accuracy of risk scores for patients with chronic hepatitis B receiving entecavir treatment. Gastroenterology. 2013 May;144(5):933-44
  10. Wong GL, Wong VW, Chan Y, et al. High incidence of mortality and recurrent bleeding in patients with Helicobacter pylori-negative idiopathic bleeding ulcers. Gastroenterology 2009 Aug;137(2):525-31.

Prof Grace L.H. WONG

Professor

Division of Gastroenterology and Hepatology
Department of Medicine and Therapeutics

Prof Vincent W.S. WONG

Division of Gastroenterology and Hepatology, Department of Medicine and Therapeutics

Contact Information
Tel: (852) 3505 1205
Email: wongv@cuhk.edu.hk

 

CUHK Employment

  • Professor, Institute of Digestive Disease
  • Head, Division of Gastroenterology and Hepatology, Department of Medicine and Therapeutics
  • Director, Cheng Suen Man Shook Centre for Hepatitis Research

Honorary appointments

  • Honorary Consultant, Prince of Wales Hospital

Expertise

  • Hepatology

Education and Qualifications

MBChB (Hons), MD (CUHK), FRCP (Edin), FHKCP, FHKAM (Medicine)

Research Interests

  • Non-alcoholic fatty liver disease
  • Chronic hepatitis B

Additional Information

Award & Honour
  • Exemplary Teachers’ Award (Medical Year 3), CUHK, 2015
  • Teacher of the Year, CUHK, 2013
  • Distinguished Research Paper Award for Young Investigators, Hong Kong College of Physicians, 2010, 2011, 2012, 2013, 2015
  • Research Excellence Award, Food and Health Bureau, Hong Kong SAR Government, 2017, 2019
Professional Service
  • Associate Editor, Clinical Gastroenterology and Hepatology

Research and Publications

  1. Wong VW, Irles M, Wong GL, Shili S, Chan AW, Merrouche W, Shu SS, Foucher J, Le Bail B, Chan WK, Chan HL, de Ledinghen V. Unified interpretation of liver stiffness measurement by M and XL probes in non-alcoholic fatty liver disease. Gut. 2019 Jan 18. doi: 10.1136/gutjnl-2018-317334. [Epub ahead of print]
  2. Wong VW, Wong GL, Chan RS, Shu SS, Cheung BH, Li LS, Chim AM, Chan CK, Leung JK, Chu WC, Woo J, Chan HL. Beneficial effects of lifestyle intervention in non-obese patients with non-alcoholic fatty liver disease. J Hepatol 2018;69:1349-1356.
  3. Wong VW, Petta S, Hiriart JB, Cammà C, Wong GL, Marra F, Vergniol J, Chan AW, Tuttolomondo A, Merrouche W, Chan HL, Le Bail B, Arena U, Craxì A, de Lédinghen V. Validity criteria for the diagnosis of fatty liver by M probe-based controlled attenuation parameter. J Hepatol 2017;67:577-584.
  4. Leung JC, Loong TC, Wei JL, Wong GL, Chan AW, Choi PC, Shu SS, Chim AM, Chan HL, Wong VW. Histological severity and clinical outcomes of nonalcoholic fatty liver disease in nonobese patients. Hepatology 2017;65:54-64.
  5. Kwok R, Choi KC, Wong GL, Zhang Y, Chan HL, Luk AO, Shu SS, Chan AW, Yeung MW, alcoholic fatty liver disease with controlled attenuation parameter and liver stiffness measurements Chan JC, Kong AP, Wong VW. Screening diabetic patients for non-: a prospective cohort study. Gut 2016;65:1359-68.
  6. Wong VW, Wong GL, Yeung JC, Fung CY, Chan JK, Chang ZH, Kwan CT, Lam HW, Limquiaco J, Chim AM, Yu CM, Chan HL. Long-term clinical outcomes after fatty liver screening in patients undergoing coronary angiogram: A prospective cohort study. Hepatology 2016;63:754-63.
  7. Wong VW, Wong GL, Yeung DK, Lau TK, Chan CK, Chim AM, Abrigo JM, Chan RS, Woo J, Tse YK, Chu WC, Chan HL. Incidence of non-alcoholic fatty liver disease in Hong Kong: a population study with paired proton-magnetic resonance spectroscopy. J Hepatol 2015;62:182-9.
  8. Wong VW, Chan RS, Wong GL, Cheung BH, Chu WC, Yeung DK, Chim AM, Lai JW, Li LS, Sea MM, Chan FK, Sung JJ, Woo J, Chan HL. Community-based lifestyle modification programme for non-alcoholic fatty liver disease: A randomized controlled trial. J Hepatol 2013;59:536-42.
  9. Wong VW, Chu WC, Wong GL, Chan RS, Chim AM, Ong A, Yeung DK, Yiu KK, Chu SH, Woo J, Chan FK, Chan HL. Prevalence of non-alcoholic fatty liver disease and advanced fibrosis in Hong Kong Chinese: A population study using proton-magnetic resonance spectroscopy and transient elastography. Gut 2012;61:409-15.
  10. Wong VW, Wong GL, Tsang SW, Fan T, Chu WC, Woo J, Chan AW, Choi PC, Chim AM, Lau JY, Chan FK, Sung JJ, Chan HL. High prevalence of colorectal neoplasm in patients with non-alcoholic steatohepatitis. Gut 2011;60:829-36.

Prof Vincent W.S. WONG

Professor

Division of Gastroenterology and Hepatology
Department of Medicine and Therapeutics

Professor Justin CY WU

Division of Gastroenterology & Hepatology, Department of Medicine & Therapeutics

Contact Information
Tel: (852) 3505 3174
Email: justinwu@cuhk.edu.hk

CUHK Employment

  • Associate Dean (Health Systems)
  • Professor, Institute of Digestive Disease
  • Professor and Founding Director, Hong Kong Institute of Integrative Medicine
  • Associate Head and Trustee, Shaw College
  • Member, The Council of CUHK
  • Director, Shaw Endoscopy Centre Prince of Wales Hospital

Honorary appointments

  • Professor, Division of Gastroenterology & Hepatology, Department of Medicine & Therapeutics
  • Associate Dean (Health Systems) | Chairman and Director
    Faculty of Medicine, The Chinese University of Hong Kong | CUHK Medical Services · HK

Expertise

  • Gastroenterology
  • Education and Qualifications

    MBChB (CUHK), MRCP (UK), MD (CUHK), FHKCP, FHKAM, FRCP (Edinburgh), FRCP (London)

    Research Interests

    • Gastroesophageal reflux disease
    • Functional gastrointestinal disorder
    • Gastrointestinal motility
    • Integrative Chinese and Western Medicine

    Additional Information

    Award & Honour
    • Leader of the Year, Hong Kong Health Awards, 2017
    • Education Award, Faculty of Medicine, 2014
    • Master Teacher, Faculty of Medicine, 2012
    • Emerging Leader in Gastroenterology, Asia Pacific Digestive Week, 2008
    • The Vice Chancellor’s Exemplary Teaching Award, 2007
    • Teacher of The Year Award, Faculty of Medicine, 2005-2008 & 2011
    Professional Service
    • Co-editor, Endoscopy
    Chairman, CUHK Medical Services
    • Chairman and Executive Councillor, Asia Diabetes Foundation
    Scientific Chairman, Asian Neurogastroenterology and Motility Association
    • President, Asian Pacific Association of Gastroenterology

    Research and Publications

    1. *Justin C Y Wu, Alexander C Ford, Cynthia K Y Cheung, Jessica Y L Ching, Yawen Chan, Joseph J Y Sung, Francis K L Chan, Pui Kuan Cheong. Low-dose imipramine for refractory functional dyspepsia: a randomised, double-blind, placebo-controlled trial. Lancet Gastroenterology & Hepatology 2018; 3: 837-844.
    2. C.K.Y. Cheung, L.L. Lan , M. Kyaw, A.D.P. Mak, A. Chan, Y. Chan J.C.Y. Wu. Up‐regulation of transient receptor potential vanilloid (TRPV) and down‐regulation of brain‐derived neurotrophic factor (BDNF) expression in patients with functional dyspepsia (FD). Neurogastroenterology & Motility 2018; 30: e13176.
    3. Cheung, C.K., Lee, Y.Y., Chan, Y., Cheong, P.K., Law, W.T., Lee, S.F., Sung, J.J., Chan, F.K., *Wu, J.C, Decreased basal and postprandial plasma serotonin levels in patients with functional dyspepsia. Clinical Gastroenterology and Hepatology 2013; 11: 1125-1129.
    4. *Wu, J.C.Y., Lai, L.H., Chow, D.K.L., Wong, G.L.H., Sung, J.J.Y., & Chan, F.K.L. Concomitant irritable bowel syndrome is associated with failure of step-down on-demand proton pump inhibitor treatment in patients with gastro-esophageal reflux disease. Neurogastroenterology & Motility, 2011; 23, 155-e31.
    5. *Wu, J.C.Y., Mui, L.M., Cheung, C.M.Y., Chan, Y., & Sung, J.J.Y. 2007. Obesity is associated with increased transient lower esophageal sphincter relaxation. Gastroenterology 2007; 132: 883-889.
    6. *Wu, J.C.Y., Cheung, C.M., Wong, V.W., & Sung, J.J.. Distinct clinical characteristics between patients with nonerosive reflux disease and those with reflux esophagitis. Clinical Gastroenterology and Hepatology 2007; 5: 690-695.
    7. *Wu, J.C.Y., Chan FKL, Ching JYL, Leung WK, Lee YT, Sung JJY. Empirical treatment based on “typical” reflux symptom is inappropriate in population with high prevalence of H. pylori infection. Gastrointest Endosc 2002: 55; 461.
    8. Chan FKL, Lai ACW, Lee YT, Wong SKH, Leung WK, Sung JJY, Wu JCY,. Effect of H. pylori eradication on esophageal acid exposure in patients with reflux esophagitis. Aliment Pharmacol Ther 2002:16; 545.
    9. *Wu, J.C.Y., Sung, J.J., Ng, E.K., Go, M.Y., Chan, W.B., Chan, F.K., Leung, W.K., Choi, C.L., & Chung, S.C.S. 1999. Prevalence and distribution of Helicobacter pylori in gastroesophageal reflux disease: a study from the East. The American Journal of Gastroenterology, 94, (7) 1790-1794.
    *as the corresponding author

Prof Justin C.Y. WU

Professor

Division of Gastroenterology and Hepatology
Department of Medicine and Therapeutics

Prof Joyce W.Y. Mak

Division of Gastroenterology and Hepatology, Department of Medicine and Therapeutics

Contact Information
Tel: (852) 3505 3307
Email: wingyanmak@cuhk.edu.hk

 

CUHK Employment

  • Assistant Professor, Institute of Digestive Disease
  • Assistant Professor, Department of Medicine and Therapeutics

Honorary appointments

  • Honorary Resident Specialist, Department of Medicine and Therapeutics, Prince of Wales Hospital

Expertise

  • Inflammatory bowel disease
  • Gut microbiota

Education and Qualifications

MBBS, MRCP (UK), FHKCP, FHKAM (Medicine)

Research Interests

  • Inflammatory bowel disease
  • Perianal Crohn’s disease
  • Gut microbiota

Additional Information

Award & Honour
  • Hong Kong College of Physicians 2018 Young Investigator Award
  • Hong Kong College of Physicians 2019 Distinguished Research Paper Award
Professional Service
  • Treasurer, Hong Kong IBD Society
Academic Engagement in CUHK
  • Academic advisor for MBChB, Faculty of Medicine, CUHK
  • Mentor, Global Physician Leadership Stream

Research and Publications

  1. Mak WY, Hart AL, Ng SC. Crohn's disease. Medicine. 2019;47(6):377-87.
  2. Mak W.Y., Ng S.C. (2019) Perianal Crohn’s Disease. In: Sheng Ding N., De Cruz P. (eds) Biomarkers in Inflammatory Bowel Diseases. Springer, Cham
  3. Buisson A, Mak WY, Andersen MJ, Lei D, Kahn SA, Pekow J, et al. Faecal Calprotectin Is a Very Reliable Tool to Predict and Monitor the Risk of Relapse After Therapeutic Deescalation in Patients With Inflammatory Bowel Diseases. J Crohns Colitis.2019;13(8):1012-24.
  4. Mak, J. W. Y., and Sung, J. J. Y. ( 2019) The Use of Biologics and Biosimilar in Asian patients with IBD: Are we ready?. Journal of Gastroenterology and Hepatology, 34: 1269– 1270.
  5. Mak, W. Y., Mak, O. S., Lee, C. K., et al. Significant Medical and Surgical Morbidity in Perianal Crohn’s Disease : Results from a Territory-Wide Study. 1392–1398 (2018).
  6. Mak WY, Buisson A, Andersen MJ, Lei D, Pekow J, Cohen RD, et al. Fecal Calprotectin in Assessing Endoscopic and Histological Remission in Patients with Ulcerative Colitis. Dig Dis Sci [Internet] 2018; Available from: http://link.springer.com/10.1007/s10620-018-4980-0.
  7. Mak, W. Y., Ng, S. C. (2018), Editorial: ways to reduce emergency department utilisation among IBD patients. Aliment Pharmacol Ther, 47: 1325-1326. doi: 10.1111/apt.14601.
  8. WY Mak, Phillip FC Lung, Ailsa Hart. In patients with perianal Crohn’s fistulas, what are the outcomes when “radiological healing” is achieved? Does radiological healing of perianal Crohn’s fistulas herald the time point for stopping a biologic? J Crohns Colitis 2017 jjx094. doi: 10.1093/ecco-jcc/jjx094.
  9. Sze, S. F., Lam, P. W. Y., Lam, Y. S., Liu, H. W., Mak, W. Y., Lam, T. W. (2016) Gastrointestinal: A rare cause of bloody diarrhea—Gastrointestinal amyloidosis. Journal of Gastroenterology and Hepatology, 31: 1913. doi: 10.1111/jgh.13440.
  10. WY Mak, YT Hui, Jodis TW Lam. Should we perform polypectomy or not? Hong Kong Med J 2014; 20:351.e3.

Prof Joyce W.Y. Mak

Honorary Associate Professor

Division of Gastroenterology and Hepatology
Department of Medicine and Therapeutics

Prof Sunny H. WONG

Division of Gastroenterology and Hepatology, Department of Medicine and Therapeutics

Contact Information
Tel: (852) 3505 3137
Email: wonghei@cuhk.edu.hk

 

CUHK Employment

  • Associate Professor, Institute of Digestive Disease
  • Associate Professor, Department of Medicine and Therapeutics
  • Assistant Professor, State Key Laboratory of Digestive Disease (CUHK)

Expertise

  • Gut microbiota
  • Colorectal cancer
  • Clostridioides difficile infection

Education and Qualifications

MBChB (Hons)(CUHK), DPhil (Oxon), FRCP (Edin), FRCPath, FHKCP, FHKAM (Medicine)

Research Interests

  • Host-microbe interaction in gastrointestinal infections and cancers

Additional Information

Award & Honour
  • Distinguished Research Paper Award for Young Investigators, Hong Kong College of Physicians (2016, 2017, 2018)
  • Hong Kong Youth Dream Maker Award (2017)
Professional Service
  • Editor, Journal of Gastroenterology and Hepatology
  • Editorial Board Member, Gut
  • Editorial Board Member, Scientific Reports
  • Council Member, Hong Kong Society for Immunology
Academic Engagement in CUHK
  • Fellow, CW Chu College
  • Coordinator for Postgraduate Student Affairs, Department of Medicine and Therapeutics
  • Coordinator for Lee Hysan Clinical Research Laboratories, Department of Medicine and Therapeutics

Research and Publications

  1. Wong SH and Yu J. Gut microbiota in colorectal cancer: mechanisms of action and clinical applications. Nat Rev Gastroenterol Hepatol; 2019 [Epub ahead of print]
  2. Wong SH, Zhao L, Zhang X et al. Gavage of fecal samples from patients with colorectal cancer promotes intestinal carcinogenesis in germ-free and conventional mice. Gastroenterology 2017;153(6):1621-33 e6.
  3. Wong SH, Kwong TN, Chow TC et al. Quantitation of faecal Fusobacterium improves faecal immunochemical test in detecting advanced colorectal neoplasia. Gut 2017;66(8):1441-48.
  4. Wong SH, Kwong TNY, Wu CY and Yu J. Clinical applications of gut microbiota in cancer biology. Semin Cancer Biol 2018 [Epub ahead of print].
  5. Kwong TNY, Wang X, Nakatsu G, Chow TC, Tipoe T, Dai RZW, Tsoi KKK, Wong MCS, Tse G, Chan MTV, Chan FKL, Ng SC, Wu JCY, Wu WKK, Yu J, Sung JJY, Wong SH. Association between bacteremia from specific microbes and subsequent diagnosis of colorectal cancer. Gastroenterology 2018;155(2):383-90 e8.
  6. Wong SH, Ip M, Hawkey PM et al. High morbidity and mortality of Clostridium difficile infection and its associations with ribotype 002 in Hong Kong. J Infect 2016;73(2):115-22.
  7. Yu J, Feng Q, Wong SH et al. Metagenomic analysis of faecal microbiome as a tool towards targeted non-invasive biomarkers for colorectal cancer. Gut 2017;66(1):70-78.
  8. Wong SH, Gochhait S, Malhotra D et al. Leprosy and the adaptation of human Toll-like receptor 1. PLoS Pathog 2010;6(7):e1000979.
  9. Wong SH, Hill AV, Vannberg FO. Genomewide association study of leprosy. N Engl J Med 2010;362(15):1446-7; author reply 47-8.
  10. Thye T, Vannberg FO, Wong SH et al. Genome-wide association analyses identifies a susceptibility locus for tuberculosis at 18q11.2. Nat Genet. 2010;42(9):739-41.

Prof Sunny H. WONG

Honorary Associate Professor

Division of Gastroenterology and Hepatology
Department of Medicine and Therapeutics

Prof Stephen L. CHAN

Department of Clinical Oncology

Contact Information
Email: chanlam_stephen@cuhk.edu.hk

 

CUHK Employment

  • Associate Professor (Clinical), Department of Clinical Oncology

Education and Qualifications

MBBS (HK), MRCP (UK), FHKCP, FHKAM (Medicine), FRCP (Edin), FRCP (Lond)

Research Interests

  • Hepatocellular carcinoma
  • Pancreatic cancer
  • Biliary tract cancer
  • Neuroendocrine tumor

Research and Publications

  1. Chan SL, Wong VW, Qin S, Chan HL. Infection and Cancer: the case of hepatitis B. J Clin Oncol .2016; 34:83-90.
  2. Chan SL, Wong AM, Lee K, Wong N, Chan AK. Personalized therapy for hepatocellular carcinoma: Where are we now? Cancer Treat Rev. 2016; 45:77-86.
  3. Chan SL, Chan AW, Yeo W. Novel Therapeutic Targets and predictive markers for hepatocellular carcinoma. Expert Opin Ther Targets. 2015; 19:973-83.
  4. Chan SL, Mo F, Johnson P, Li L, Tang N, Loong H, Chan AW, Koh J, Chan AT, Yeo W. Applicability of BALAD score in prognostication of hepatitis B-related hepatocellular carcinoma. J Gastroenterol Hepatol. 2015; 30:1529-35.
  5. Chan SL, Wong CH, Lau CP, Zhou Q, Hui CW, Lui VW, Ma BB, Chan AT, Yeo W. Preclinical evaluation of combined TKI-258 and RAD-001 in hepatocellular carcinoma. Cancer Chemother Pharmacol. 2013; 71:1417-252
  6. Chan SL, Mo F, Wong SC, Chan CM, Leung LK, Hui EP, Ma BB, Chan AT, Mok TS, Yeo W. A study of Circulating Interleukin-10 in Prognostication of Unresectable Hepatocellular Carcinoma. Cancer. 2012; 118: 3984-92.
  7. Chan SL, Mo FK, Johnson PJ, Liem GS, Chan TC, Poon MC, Ma BB, Leung TW, Lai PB, Chan AT, Mok TS, Yeo W. Prospective validation of the Chinese University Prognostic Index andcomparison with other staging systems for hepatocellular carcinoma in an Asian population. J Gastroenterol Hepatol. 2011; 26:340-7.
  8. Wong VW*, Chan SL*, Mo F, Chan TC, Loong HH, Wong GL, Lui YY, AT Chan, Sung JJ, Yeo W, Chan HL, Mok TS. A clinical scoring system to predict hepatocellular carcinoma in chronic hepatitis B carriers. (*equal contribution). J Clin Oncol. 2010; 28:1660-65.
  9. Chan SL, Mok T. PARP inhibition in BRCA-mutated breast and ovarian cancers. Lancet. 2009; 376:211-3.
  10. Chan SL, Mo F, Johnson PJ, Hui EP, Ma BB, Ho WM, Lam KC, Chan AT, Mok TS, Yeo W. Anew utility of old marker: serial alpha-fetoprotein measurement in predicting radiological response and survival of patients with hepatocellular carcinoma undergoing systemic chemotherapy. J Clin Oncol. 2009; 27:446-52.

Prof Stephen L. CHAN

Associate Professor

Department of Clinical Oncology

Prof Raymond S.Y. TANG

Division of Gastroenterology and Hepatology, Department of Medicine and Therapeutics

Contact Information
Email: raymondtang@cuhk.edu.hk

CUHK Employment

  • Assistant Professor, Institute of Digestive Disease
  • Assistant Professor, Department of Medicine and Therapeutics
  • Director, S.H. Ho Centre for Digestive Health, Institute of Digestive Disease

Honorary appointments

  • Deputy Director, Endoscopy Centre, Prince of Wales Hospital

Expertise

  • Advanced endoscopy (EUS, ERCP, deep enteroscopy)
  • Pancreatobiliary diseases, GI bleeding

Education and Qualifications

  • MD (USC, USA)
  • Diplomate, American Board of Internal Medicine (Internal Medicine)
  • Diplomate, American Board of Internal Medicine (Gastroenterology)

Research Interests

  • Advanced Endoscopy (EUS, ERCP, deep enteroscopy)
  • Pancreatic cystic neoplasm
  • GI cancer
  • GI Bleeding

Additional Information

Award & Honour
  • American Society for Gastrointestinal Endoscopy (ASGE) Video Editing Scholarship 2010
  • Best Clinical Poster Award, Annual Meeting of American Pancreatic Association 2007
Professional Service
  • Secretary and council member, The Hong Kong Society of Endosonography. 2016—present
  • Faculty member, Asian EUS Group. 2013—present
  • Editorial board member, Clinical Gastroenterology and Hepatology. 10/2013 - 1/2019.
Academic Engagement in CUHK
  • Teaching faculty, Master of Science in Gastroenterology, Institute of Digestive Disease, The Chinese University of Hong Kong
  • Mentor, Endoscopy Attachment Program, Institute of Digestive Disease, The Chinese University of Hong Kong
  • Member of organizing committee, The International Digestive Disease Forum, The Chinese University of Hong Kong
  • Member of organizing committee, International Workshop on Therapeutic Endoscopy, The Chinese University of Hong Kong

Research and Publications

  1. Maydeo AP, Rerknimitr R, Lau JY, Aljebreen A, Niaz SK, Itoi T, Ang TL, Reichenberger J, Seo DW, Ramchandani MK, Devereaux BM, Lee JK, Goenka MK, Sud R, Nguyen NQ, Kochhar R, Peetermans J, Goswamy PG, Rousseau M, Bhandari SP, Angsuwatcharakon P, Tang RSY, Teoh AYB, Almadi M, Lee YN, Moon JH; SpyGlass AMEA Registry Group. Cholangioscopy-guided lithotripsy for difficult bile duct stone clearance in a single session of ERCP: results from a large multinational registry demonstrate high success rates. Endoscopy. 2019 Oct;51(10):922-929.
  2. Tang RS. Endoscopic ultrasound-guided vascular intervention for portal hypertension. Gastrointestinal Intervention 2017 July; 6(2): 130-134.
  3. Tang RS, Chan FK, Lau JW. Chapter 73. Upper and Lower Gastrointestinal Hemorrhage. Surgery: Core principles and Practice. 2nd Revised Edition. John D Corson, Robin Williamson. April 2017.
  4. Wong JC, Tang RS, Teoh AY, Sung JJ, Lau JY. Efficacy and safety of novel digital single-operator peroral cholangioscopy-guided laser lithotripsy for complicated biliary stones. Endosc Int Open 2017 Jan; 05(01): E54-E58.
  5. Tang RS, Teoh AY, Lau JY. EUS-guided cyanoacrylate injection for treatment of endoscopically obscured bleeding gastric varices. Gastrointest Endosc. 2016 May; 83 (5): 1032-3.
  6. Tang RS, Savides TJ. Chapter 17. Gastrointestinal subepithelial masses. Endoscopic Ultrasonography. 3rd Edition. Frank G. Gress, Thomas J Savides. January 2016.
  7. Tang RS, Savides TJ. Chapter 23. Management of Cystic Lesions of the Pancreas. Pancreatic Masses: Advances in Diagnosis and Therapy.1st Ed. Mihir S. Wagh, Peter V. Draganov. November 2015.
  8. Teoh AY, Tang RS. Clinical evaluation of new diagnostic modalities of endoscopic ultrasound for pancreaticobiliary diseases. Dig Endosc. 2015 Apr; 27; Suppl 1: 55-9.
  9. Lee RH, Tang RS, Muthusamy VR, Ho SB, Shah NK, Wetzel L, Bain AS, Mackintosh EE, Paek AM, Crissien AM, Saraf LJ, Kalmaz DM, Savides TJ. Quality of Colonoscopy Withdrawal Technique and Variability in Adenoma Detection Rates. Gastrointest Endosc. 2011 Jul; 74(1): 128-34.
  10. Tang RS, Weinberg B, Dawson DW, Reber H, Hines OJ, Tomlinson JS, Chaudhari V, Raman S, Farrell JJ. Evaluation of the guidelines for management of pancreatic branch-duct intraductal papillary mucinous neoplasm. Clin Gastroenterol Hepatol. 2008 Jul; 6(7): 815-9.

Prof Raymond S.Y. TANG

Assistant Professor

Division of Gastroenterology and Hepatology
Department of Medicine and Therapeutics

Prof Louis H.S. Lau

Division of Gastroenterology and Hepatology, Department of Medicine & Therapeutics

Contact Information
Tel: (852) 2693 9549
Email: thomaslam@cuhk.edu.hk

CUHK Employment

  • Assistant Professor (Clinical), Department of Medicine and Therapeutics
    Consultant, CUHK Medical Centre

Honorary Appointments

  • Honorary Resident Specialist, Prince of Wales Hospital

Expertise

  • Advanced endoscopy
  • Gastrointestinal bleeding

Education and Qualifications

MBChB, MRCP (UK), FRCP (London), FHKCP, FHKAM (Medicine)

Research Interests

  • Antithrombotics and gastrointestinal bleeding
  • Endoscopic treatment of gastrointestinal cancers
  • Application of big data research and artificial intelligence in medicine

ADDITIONAL INFORMATION

Award & Honour
  • APAGE Research Programme Award, The Asian Pacific Association of Gastroenterology, 2024
  • Emerging Stars, World Endoscopy Organization, 2022
  • National Scholar Award, United European Gastroenterology Week, 2022
  • Distinguished Research Paper Award for Young Investigators, Hong Kong College of Physicians, 2021
  • Outstanding Team Award (Endoscopy Team), Hospital Authority, 2021
  • Distinguished Young Fellow, Hong Kong Academy of Medicine, 2020
  • Gold Medal, Best Thesis Award, Hong Kong College of Physicians, 2019

Professional Service

  • Co-opted Council Member, The Hong Kong Society of Gastroenterology, 2024
  • Editorial Board Member, Gastroenterology, 2024
  • Editorial Board Member, Alimentary Pharmacology & Therapeutics, 2024
  • Faculty Member, Asian Novel Bio-Imaging and Intervention Group (ANBIIG), 2021

RESEARCH AND PUBLICATIONS

  1. Lau LHS, Ho JCL, Lai JCT, Ho AHY, Wu CWK, Lo VWH, Lai CMS, Scheppach MW, Sia F, Ho KHK, Xiao X, Yip TCF, Lam TYT, Kwok HYH, Chan HCH, Lui RN, Chan TT, Wong MTL, Ho MF, Ko RCW, Hon SF, Chu S, Futaba K, Ng SSM, Yip HC, Tang RSY, Wong VWS, Chan FKL, Chiu PWY; ENDOAID-TRAIN study group. Effect of Real-Time Computer-Aided Polyp Detection System (ENDO-AID) on Adenoma Detection in Endoscopists-in-Training: A Randomized Trial. Clin Gastroenterol Hepatol. 2024 Mar;22(3):630-641.e4.
  2. Lau RI, Su Q, Lau ISF, Ching JYL, Wong MCS, Lau LHS, Tun HM, Mok CKP, Chau SWH, Tse YK, Cheung CP, Li MKT, Yeung GTY, Cheong PK, Chan FKL, Ng SC. A synbiotic preparation (SIM01) for post-acute COVID-19 syndrome in Hong Kong (RECOVERY): a randomised, double-blind, placebo-controlled trial. Lancet Infect Dis. 2024 Mar;24(3):256-265
  3. Yau YK, Lau LHS, Lui RNS, Wong SH, Guo CL, Mak JWY, Ching JYL, Ip M, Kamm MA, Rubin DT, Chan PKS, Chan FKL, Ng SC. Long-Term Safety Outcomes of Fecal Microbiota Transplantation: Real-World Data Over 8 Years From the Hong Kong FMT Registry. Clin Gastroenterol Hepatol. 2024 Mar;22(3):611-620.e12.
  4. Lau LHS, Jiang W, Guo CLT, Lui RN, Tang RSY, Chan FKL. Effectiveness of prophylactic clipping in preventing postpolypectomy bleeding in aspirin users: a propensity-score analysis. Gastrointest Endosc. 2023 Mar;97(3):517-527.e1.
  5. Lau LHS, Guo CLT, Lee JKK, Chan CST, Mak JWY, Wong SH, Yip TCF, Wong GLH, Wong VWS, Chan FKL, Tang RSY. Effectiveness of prophylactic clipping in preventing postpolypectomy bleeding in oral anticoagulant users: a propensity-score analysis. Gastrointest Endosc. 2022 Sep;96(3):530-542.e1..
  6. Guo CLT, Wong SH, Lau LHS, Lui RNS, Mak JWY, Tang RSY, Yip TCF, Wu WKK, Wong GLH, Chan FKL, Lau JYW, Sung JJY. Timing of endoscopy for acute upper gastrointestinal bleeding: a territory-wide cohort study. Gut. 2022 Aug;71(8):1544-1550.
  7. Lau LH, Guo CL, Yip TC, Mak JW, Wong SH, Lam KL, Wong GL, Ng SC, Chan FK. Risks of post-colonoscopic polypectomy bleeding and thromboembolism with warfarin and direct oral anticoagulants: a population-based analysis. Gut. 2022 Jan;71(1):100-110.
  8. Lau LHS, Wong SH, Yip TCF, Wong GLH, Wong VWS, Sung JJY. Collateral Effect of Coronavirus Disease 2019 Pandemic on Hospitalizations and Clinical Outcomes in Gastrointestinal and Liver Diseases: A Territory-wide Observational Study in Hong Kong. Gastroenterology. 2020 Nov;159(5):1979-1981.e3.
  9. Wong GLH, Lau LHS, Ching JYL, Tse YK, Ling RHY, Wong VWS, Chiu PWY, Lau JYW, Chan FKL. Prevention of recurrent idiopathic gastroduodenal ulcer bleeding: a double-blind, randomised trial. Gut. 2020 Apr;69(4):652-657.
  10. Lau JYW, Yu Y, Tang RSY, Chan HCH, Yip HC, Chan SM, Luk SWY, Wong SH, Lau LHS, Lui RN, Chan TT, Mak JWY, Chan FKL, Sung JJY. Timing of Endoscopy for Acute Upper Gastrointestinal Bleeding. N Engl J Med. 2020 Apr 2;382(14):1299-1308.

Prof Louis H.S. Lau

Assistant Professor

Division of Gastroenterology and Hepatology
Department of Medicine and Therapeutics

Prof Dennis C.C. WONG

State Key Laboratory of Digestive Disease (CUHK)

Contact Information
Email: chichun.wong@cuhk.edu.hk

 

CUHK Employment

  • Assistant Professor, Department of Medicine and Therapeutics

Expertise

  • Basic research in gastrointestinal cancers

Education and Qualifications

BSc, MPhil, PhD

Research Interests

  • Molecular basis of gastrointestinal cancers
  • Cancer Metabolism
  • Cancer Therapeutics

Additional Information

Award & Honour
  • 2016 & 2019, Young Investigator Award, Digestive Disease Week
  • 2016, 2017 & 2018, Travel Award, United European Gastroenterology Week
  • 2007 Li Ka Shing Prize in the Faculties of Dentistry, Engineering, Medicine and Science in HKU
Professional Service
  • Reviewer for Oncogene, Molecules, RCS advances, Scientific Reports, Life Sciences.
Academic Engagement in CUHK
  • Postgraduate Supervision: Supervision of PhD candidates

Research and Publications

  1. Wong CC#, Kang W, Xu J, Qian Y, Luk STY, Chen H, Li W, Zhao L, Zhang X, Chiu PWY, Ng EKW, Yu J. Prostaglandin E2 induces DNA hypermethylation in gastric cancer in vitro and in vivo. Theranostics, 2019, in press.
  2. Long X, Wong CC, Li T, Chan FK, Yu J. Peptostreptococcus anaerobius promotes colorectal carcinogenesis and modulates tumor-immunity by activating PI3K/Akt signaling via its PCWBR2 adhesin, Nature Microbiology, 2019, in press.
  3. Zhang L, Li W, Cao L, Xu J, Qian Y, Chen H, Zhang Y, Kang W, Gou H, Wong CC#, Yu J#. PKNOX2 suppresses gastric cancer through the transcriptional activation of IGFBP5 and p53, Oncogene, 2019, 38(23):4590-604.
  4. Wong CC#, Li W, Chan BWH, Yu J. Epigenomic biomarkers for prognostication and diagnosis of gastrointestinal cancers. Seminars in Cancer Biology, 2019, 55:90-105.
  5. Li W*, Wong CC*, Zhang X, Kang W, Nakatsu D, Zhao Q, Chen H, Go YY, Chiu PW, Ng EK, Yu J. CAB39L elicited an anti-Warburg effect via a LKB1-AMPK-PGC1α axis to inhibit gastric tumorigenesis. Oncogene, 2018, 37(50):6383-98.
  6. Liu D, Wong CC, Fu L, Chen H, Zhao L, Li C, Zhou Y, Zhang Y, Xu W, Yang Y, Wu B, Cheng G, Lai PB, Wong N, Sung JJ, Yu J. Squalene epoxidase drives nonalcoholic fatty liver disease-induced hepatocellular carcinoma and is a pharmaceutical target. Science Translational Medicine, 2018, 10(437), eaap9840.
  7. Qian Y*, Wong CC*, Xu, J, Chen H, Zhang Y, Kang W, Wang H, Zhang L, Li W, Chu ES, Go MY, Chiu PWY, Ng EKW, Chan FKL, Sung JJY, Si J, Yu J. Sodium channel subunit SCNN1B suppresses gastric cancer growth and metastasis via GRP78 degradation. Cancer Research, 2017, 77, 1968-1982.
  8. Wong CC#, Qian Y, Yu J#. Interplay between epigenetics and metabolism in oncogenesis: mechanisms and therapeutic approaches. Oncogene, 2017, 36(24), 3359-3374.
  9. Wong CC#, Qian Y, Li X, Xu J, Kang W, Tong JH, To KF, Jin Y, Li W, Chen H, Go MY, Cheng KW, Wu JL, Sung JY, Cai Z, Yu J#. SLC25A22 promotes proliferation and survival of colorectal cancer cells with KRAS mutations and xenograft tumor progression in mice via intracellular synthesis of aspartate. Gastroenterology, 2016, 151, 945-960.
  10. Qian Y*, Wong CC*, Lai S, Chen H, He X, Sun L, Wu J, Zhou J, Yu J, Liu W, Zhou D, Si J. A retrospective study of pyogenic liver abscess focusing on Klebsiella pneumoniae as a primary pathogen in China from 1994 to 2015. Scientific Reports, 2016, 6, 38587.

Prof Dennis C.C. WONG

Assistant Professor

State Key Laboratory of Digestive Disease (CUHK)

Prof William K.K. WU

Department of Anaesthesia and Intensive Care

Contact Information
Email:wukakei@cuhk.edu.hk

CUHK Employment

  • Associate Professor (Non-clinical), Department of Anaesthesia and Intensive Care
  • Principal Investigator, State Key Laboratory of Digestive Diseases
  • Principal Investigator, Li Ka Shing Institute of Health Sciences
  • Principal Investigator, Centre for Gut Microbiota Research
  • Research Fellow (Honorary), Peter Hung Pain Research Institute

Expertise

  • Autophagy and ubiquitin-proteasome system
  • Cancer biology and genomics
  • Gut microbiota

Education and Qualifications

BSc (Hons), MMedSc (Distinction), MPhil, PhD, FRCPath, FRCP (Edin), FRCPS (Glasg)

Research Interests

  • Gastrointestinal and liver tumorigenesis
  • Sepsis-associated gut barrier dysfunction
  • Gut-brain axis in chronic pain

Additional Information

Award & Honour
  • Second-class State Natural Science Award, China, 2016
  • Young Researcher Award, CUHK, 2015
  • First-class Higher Education Outstanding Scientific Research Output Award (Natural Science), Ministry of Education, China, 2015
  • Sir Edward Youde Memorial Fellowship, Sir Edward Youde Memorial Fund, 2007
  • Wong Ching Yee Medical Scholarship, HKU, 2006
  • Outstanding Research Postgraduate Student Award, HKU, 2005
Professional Service
  • Editorial Board Member, Scientific Reports
  • Editorial Board Member, Journal of Pharmacy and Pharmacology
  • Council Member, Hong Kong Society for Immunology
  • Council Member, Hong Kong Society of Flow Cytometry

Research and Publications

  1. Huang D, Wang X, Liu Y, Huang Z, Hu X, Hu W, Li Q, Chan H, Zou Y, Ho IHT, Wang Y, Cheng ASL, Kang W, To KF, Wang MHT, Wong SH, Yu J, Gin T, Zhang Q, Li Z, Shen J, Zhang L, Chan MTV, Liu X, Wu WKK (2021) Multi-omic analysis suggests tumor suppressor genes evolved specific promoter features to optimize cancer resistance. Briefings in Bioinformatics doi: 10.1093/bib/bbab040.
  2. Li Q, Hu W, Liu WX, Zhao LY, Huang D, Liu XD, Chan H, Zhang Y, Zeng JD, Coker OO, Kang W, Ng SSM, Zhang L, Wong SH, Gin T, Chan MTV, Wu JL, Yu J, Wu WKK (2021) Streptococcus thermophilus inhibits colorectal tumorigenesis through secreting β-galactosidase. Gastroenterology 160(4):1179-1193.
  3. Ho J, Chan H, Liang Y, Liu X, Zhang L, Li Q, Zhang Y, Zeng J, Ugwu FN, Ho IHT, Hu W, Yau JCW, Wong SH, Wong WT, Ling L, Cho CH, Gallo RL, Gin T, Tse G, Yu J, Chan MTV, Leung CCH, Wu WKK (2020) Cathelicidin preserves intestinal barrier function in polymicrobial sepsis. Critical Care 24(1):47.
  4. Ho J, Li X, Zhang L, Liang Y, Hu W, Yau JCW, Chan H, Gin T, Chan MTV, Tse G, Wu WKK (2019) Translational genomics in pancreatic ductal adenocarcinoma: a review with re-analysis of TCGA dataset. Seminars in Cancer Biology 55:70-77.
  5. Wang X, Li X, Zhang L, Wong SH, Wang MHT, Tse G, Dai RZW, Nakatsu G, Coker OO, Chen Z, Ko H, Chan JYK, Liu T, Cheng CHK, Cheng ASL, To KF, Plewczynski D, Sung JJY, Yu J, Gin T, Chan MTV, Wu WKK (2018) Oncogenes expand during evolution to withstand somatic amplification. Annals of Oncology 29(11):2254-2260.
  6. Zhang L, Hu W, Cho CH, Chan FK, Yu J, Ross Fitzgerald J, Cheung CK, Xiao ZG, Shen J, Li LF, Li MX, Wu JC, Ling TK, Chan JY, Ko H, Tse G, Ng SC, Yu S, Wang MH, Gin T, Ashktorab H, Smoot DT, Wong SH, Chan MT, Wu WKK (2018) Reduced lysosomal clearance of autophagosomes promotes survival and colonization of Helicobacter pylori. Journal of Pathology 244(4):432-444.
  7. Wu WKK, Li X, Wang X, Dai RZW, Cheng ASL, Wang MHT, Kwong T, Chow TC, Yu J, Chan MTV, Wong SH (2017) Oncogenes without a neighboring tumor-suppressor gene are more prone to amplification. Molecular Biology and Evolution 34(4):903-907.
  8. Wong XJ, Yu J, Wong, SH, Cheng ASL, Chan FKL, Ng SSM, Cho CH, Sung JJY, Wu WKK (2013) A novel crosstalk between two major protein degradation systems: regulation of proteasomal activity by autophagy. Autophagy 9(10):1500-08.
  9. Wu WKK, Cho CH, Lee CW, Wu YC, Yu L, Li ZJ, Wong CCM, Li HT, Zhang L, Ren SX, Che CT, Wu K, Fan D, Yu J, Sung JJY (2010) Macroautophagy and ERK phosphorylation counteract the anti-proliferative effect of proteasome inhibitor in gastric cancer cells. Autophagy 6(2):228-238.
  10. Wu WKK, Wong HPS, Luo SW, Chan K, Huang FY, Hui MKC, Lam EKY, Shin VY, Ye YN, Yang YH, Cho CH (2005) 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone from cigarette smoke stimulates colon cancer growth via beta-adrenoceptors. Cancer Research 65(12):5272-7.

Prof William K.K. WU

Associate Professor

Department of Anaesthesia and Intensive Care

Prof. Terry C.F YIP

Assistant Professor

Contact Information
Email: tcfyip@cuhk.edu.hk

CUHK EMPLOYMENT

  • Assistant Professor (non-clinical), Department of Medicine & Therapeutics
  • Assistant Director, Medical Data Analytics Centre (MDAC)

EXPERTISE

  • viral hepatitis
  • Non-alcoholic fatty liver disease
  • Biostatistics
  • Big Data in Medicine

EDUCATION AND QUALIFICATIONS

  • BSc (CUHK), MPhil (CUHK), PhD (CUHK)

RESEARCH INTERESTS

  • Viral hepatitis
  • Non-alcoholic fatty liver disease
  • Epidemiology
  • Health registry data research

ADDITIONAL INFORMATION

Award & Honour
  • Young Investigator Award, Asian-Pacific Association for the Study of the Liver, 2018, 2022, 2023
  • Young investigator bursary, European Association for the Study of the Liver, 2020, 2021, 2022, 2023
  • Presidential Poster of Distinction, American Association for the Study of Liver Diseases, 2018, 2022
  • APDWF-JGHF Educational Grant, Asian Pacific Digestive Week, 2021
  • Early Career Investigator Award in Clinical/Translational Science, American Association for the Study of Liver Diseases, 2020
  • Hong Kong PhD Fellowship Scheme, Research Grants Council, 2016-2019
  • Sir Edward Youde Memorial Fellowship for Postgraduate Research Students, Sir Edward Youde Memorial Fund, 2018

Professional Service

  • Associate Editor, Journal of Hepatology
  • Associate Editor, Frontiers in Gastroenterology - Hepatology
  • Associate Editor, Frontiers in Medicine - Hepatobiliary Diseases

Academic Engagement in CUHK

  • Associate Director, Master of Science Programme in Gastroenterology

RESEARCH AND PUBLICATIONS

  1. Yip TC, Wong VW, Lui GC, Chow VC, Tse YK, Hui VW, Liang LY, Chan HL, Hui DS, Wong GL. Current and Past
    Infections of HBV Do Not Increase Mortality in Patients With COVID-19. Hepatology. 2021;74:1750-1765.
  2. Yip TC, Lui GC, Wong VW, Chow VC, Ho TH, Li TC, Tse YK, Hui DS, Chan HL, Wong GL. Liver injury is
    independently associated with adverse clinical outcomes in patients with COVID-19. Gut. 2021;70:733-742.
  3. Yip TC, Wong VW, Chan HL, Tse YK, Lui GC, Wong GL. Tenofovir Is Associated With Lower Risk of Hepatocellular
    Carcinoma Than Entecavir in Patients With Chronic HBV Infection in China. Gastroenterology.
    2020;158:215-225.e6.
  4. Yip TC, Wong GL, Wong VW, Tse YK, Liang LY, Hui VW, Lee HW, Lui GC, Chan HL. Reassessing the accuracy of
    PAGE-B-related scores to predict hepatocellular carcinoma development in patients with chronic hepatitis B.
    J Hepatol. 2020;72:847-854.
  5. Yip TC, Wong GL, Chan HL, Tse YK, Lam KL, Lui GC, Wong VW. HBsAg seroclearance further reduces
    hepatocellular carcinoma risk after complete viral suppression with nucleos(t)ide analogues. J Hepatol.
    2019;70:361-370.
  6. Yip TC, Chan HL, Tse YK, Lam KL, Lui GC, Wong VW, Wong GL. On-Treatment Improvement of MELD Score Reduces
    Death and Hepatic Events in Patients With Hepatitis B-Related Cirrhosis. Am J Gastroenterol.
    2018;113:1629-1638.
  7. Yip TC, Wong VW, Chan HL, Tse YK, Kong AP, Lam KL, Lui GC, Wong GL. Effects of Diabetes and Glycemic Control
    on Risk of Hepatocellular Carcinoma After Seroclearance of Hepatitis B Surface Antigen. Clin Gastroenterol
    Hepatol. 2018;16:765-773.e2.
  8. Yip TC, Wong GL, Wong VW, Tse YK, Lui GC, Lam KL, Chan HL. Durability of hepatitis B surface antigen
    seroclearance in untreated and nucleos(t)ide analogue-treated patients. J Hepatol. 2018;68:63-72.
  9. Yip TC, Chan HL, Wong VW, Tse YK, Lam KL, Wong GL. Impact of age and gender on risk of hepatocellular
    carcinoma after hepatitis B surface antigen seroclearance. J Hepatol. 2017;67:902-908.
  10. Yip TC, Ma AJ, Wong VW, Tse YK, Chan HL, Yuen PC, Wong GL. Laboratory parameter-based machine learning model
    for excluding non-alcoholic fatty liver disease (NAFLD) in the general population. Aliment Pharmacol Ther.
    2017;46:447-456.

Prof. Terry C.F YIP

Assistant Professor

Department of Medicine & Therapeutics

Mr Thomas Y.T. LAM

Research Assistant Professor, JC School of Public Health and Primary Care, Faculty of Medicine

Contact Information
Email: thomaslam@cuhk.edu.hk

 

CUHK Employment

  • Research Assistant Professor, JC School of Public Health and Primary Care
  • Associate Director, S.H. Ho Centre for Digestive Health, Institute of Digestive Disease
  • Manager, CUHK Jockey Club Multi-Cancer Prevention Program, JC School of Public Health

Education and Qualifications

RN, BN (Hons), MSc, PhD

Research Interests

  • Digital health
  • Cancer screening
  • Endoscopy nursing
  • Big data science
Dr Thomas Lam is a registered nurse specialised in endoscopy and cancer screening. He obtained his Bachelor of Nursing, followed by MSc in Gastroenterology and PhD in Medical Science at the Chinese University of Hong Kong. His research interest lies at the utilization of Digital Health technologies to improve healthcare delivery. His research contributions have been to design strategies of using Short Message Service (SMS) and mobile messenger (WhatsApp) to improve adherence and quality of colorectal cancer screening. He has recently broadened his interest to big data science. His research track record is exemplified by his authoring of over 40 research articles, including some published in top journals in Gastroenterology / Hepatology and Primary Health Care. He has also received the Young Investigator Award in the Digestive Disease Week for his research excellence.

Mr Thomas Y.T. LAM

Research Assistant Professor

JC School of Public Health

Prof Jessie Qiaoyi LIANG

Department of Medicine & Therapeutics

Contact Information
Email: JessieQY@cuhk.edu.hk

CUHK Employment

  • Research Associate Professor, Department of Medicine & Therapeutics, CUHK

Honorary Employment

  • Professor (by courtesy), Shenzhen Research Institute, CUHK

Expertise

  • Genomics, Gastrointestinal cancers, new markers and molecular diagnostics

Education and Qualifications

Ph.D. in Oncology, B.S. in Biological Sciences

Research Interests

  • Microbiome in health and disease
  • Human endogenous retroviruses
  • Cancer genomics and epigenetics
  • Molecular and translational medicine

Additional Information

Award & Honour
  • Poster of Distinction, Digestive Disease Week 2019, San Diego, USA 05/2019
  • Scientific Accomplishment as an Early Career Investigator, American Gastroenterological Association, 05/2018
  • Health and Medical Research Fund Research fellowship, Food and Health Bureau, Hong Kong, 10/2017
  • State Scientific & Technological Progress Award (SSTPA), Ministry of Science and Technology, China, 12/2016
  • Women Scientists Award, the 10th International Conference on Genomics (ICG-10) Conference Committee, 2015
  • Oral Free Paper Prize, UEG Week 2015, UEG Scientific Committee, 10/2015
  • Travel Award for UEG Week 2015, UEG Scientific Committee, 05/2015
  • Research Excellence Award 2014-15, Faculty of Medicine, The Chinese University of Hong Kong, 2015
  • AACR Travel Prize and Best Poster Award, American Association for Cancer Research, 10/2014
  • HK Quality Migrant Admission Scheme Awardee 2012
Professional Service
  • Editorial board member, Frontiers in Oncology
  • Member, the American Gastroenterological Association (AGA)
  • Member, Anti-Cancer Association of China
  • Member, Chronic Disease Management of China Medicinal Biotech Association
  • Secretary and Member, Cross-Strait Microbiological Cooperation Committee
  • Member, Hong Kong Society of Immunology
  • Member, Hong Kong Society of Flow Cytometry

Research and Publications

  1. Liang JQ# (corresponding), Li T, Chen YX, Yau TO, Nakatsu G, Chu ESH, Wong S, Szeto CH, Ng SC, Chan FK, Fang JY, Sung JJ, Yu J#. A Novel Fecal Lachnoclostridium Marker for the Non-Invasive Diagnosis of Colorectal Adenoma and Cancer. Gut 2019 Sep 12 DOI 10.1136/gutjnl-2019-318532. (IF2019: 19.819)
  2. Liang JQ, Teoh N*, Xu L, Pok S, Li X, Chu ESH, Chiu J, Dong L, Arfianti E, Haigh WG, Yeh MM, Ioannou GN, Sung JJ, Wong N, Farrell G#, Yu J#. Dietary cholesterol promotes steatohepatitis related hepatocellular carcinoma by inducing aberrant gene expression in metabolism and mutations in calcium signaling. Nat Commun. 2018 Oct 26;9(1):4490. doi: 10.1038/s41467-018-06931-6. (IF2019: 12.121)
  3. Gou H, Liang JQ*(co-first)), Zhang L, Chen H, Zhang Y, Li R, Wang X, Ji J, Tong JH, To KF, Sung JJ, Chan FK, Fang JY, Yu J#. TTPAL promotes colorectal tumorigenesis by stabilizing TRIP6 to activate Wnt/β-catenin signaling. Cancer Res. 2019 Jul 1;79(13):3332-3346. doi: 10.1158/0008-5472.CAN-18-2986. Epub 2019 Apr 24. (IF2019: 9.727)
  4. Zhang M, Liang JQ#(corresponding), Zheng S#. Expressional activation and functional roles of human endogenous retroviruses in cancers. Rev Med Virol. 2019 Mar;29(2):e2025. doi: 10.1002/rmv.2025. Epub 2019 Jan 6. (IF2019: 4.221)
  5. Liang Q# (corresponding), Chiu J, Chen Y, Huang Y, Higashimori A, Fang J, Brim H, Ashktorab H, Ng SC, SM Ng SSM, Zheng S, Chan FK, Sung JJ, Yu J#. Fecal Bacteria Act as Novel Biomarkers for Non-Invasive Diagnosis of Colorectal Cancer. Clin Cancer Res. 2017 Apr 15;23(8):2061-2070. doi: 10.1158/1078-0432.CCR-16-1599. (IF2019: 10.107)
  6. Wang K*, Liang Q*(co-first), Li X, Tsoi H, Zhang J, Wang H, Go MY, Chiu PW, Ng EK, Sung JJ, Yu J. MDGA2 is a novel tumor suppressor cooperating with DMAP1 in gastric cancer and is associated with disease outcome. Gut. 2016 Oct;65(10):1619-31. doi: 10.1136/gutjnl-2015-309276. (IF2019: 19.819)
  7. Shen J*, Tsoi H*, Liang Q*(co-first) ), Chu ESH, Liu D, Li X, Wong VW, Sung JJ, Yu J. Oncogenic mutations and dysregulated pathways in obesity-associated hepatocellular carcinoma. Oncogene. 2016 Dec 8;35(49):6271-6280. doi: 10.1038/onc.2016.162. (IF2019: 7.971)
  8. Yu J*, Feng Q*, Wong SH*, Zhang D*, Liang QY*(co-first)), Qin Y, Tang L, Zhao H, Stenvang J, Li Y, Wang X, Xu X, Chen N, Wu WK, Al-Aama J, Nielsen HJ, Kiilerich P, Jensen BA, Yau TO, Lan Z, Jia H, Li J, Xiao L, Lam TY, Ng SC, Cheng AS, Wong VW, Chan FK, Xu X, Yang H, Madsen L, Datz C, Tilg H, Wang J, Brünner N, Kristiansen K, Arumugam M#, Sung JJ#, Wang J#. Metagenomic analysis of fecal microbiome as a tool towards targeted non-invasive biomarkers for colorectal cancer. Gut. 2017 Jan;66(1):70-78. doi: 10.1136/gutjnl-2015-309800. (IF2019: 19.819)
  9. Liang Q, Yao X, Tang S, Zhang J, Yau TO, Li X, Tang CM, Kang W, Lung RW, Li JW, Chan TF, Xing R, Lu Y, Lo KW, Wong N, To KF, Yu C, Chan FK, Sung JJ, Yu J. Integrative Identification of Epstein-Barr Virus-associated Mutations and Epigenetic Alterations in Gastric Cancer. Gastroenterology. 2014 Dec;147(6):1350-1362.e4. doi: 10.1053/j.gastro.2014.08.036. (IF2019: 17.373)
  10. Xie X, Liang Q# (corresponding). Establishment of a 10-plex Quantitative Fluorescent-PCR Assay for Rapid Diagnosis of Sex Chromosome Aneuploidies. PLoS One. 2014 Sep;9(9):e106307. doi: 10.1371/journal.pone.0106307. (IF2019: 2.740)

Prof Jessie Qiaoyi LIANG

Research Associate Professor

Department of Medicine and Therapeutics

Prof Jennifer Xiang ZHANG

State Key Laboratory of Digestive Disease (CUHK)

Contact Information
Tel: (852)3763 6102
Email: jenniferzhang@link.cuhk.edu.hk

 

CUHK Employment

  • Research Assistant Professor, Institute of Digestive Disease
  • Research Assistant Professor, Department of Medicine and Therapeutics
  • Research Assistant Professor, State Key Laboratory of Digestive Disease (CUHK)

Honorary Employment

  • Associate Research Fellow, Shenzhen Research Institute, CUHK

Expertise

  • Non-alcoholic fatty liver disease and its associated liver cancer

Education and Qualifications

MB, MM (XJTU), PhD (CUHK)

Research Interests

  • The mechanism, diagnosis and therapeutic targets of non-alcoholic fatty liver diseases and its associated liver cancer.
  • Gut microbiome and molecular alterations in colorectal cancer and hepatocellular carcinoma.

Additional Information

Award & Honour
  • Poster of Distinction, American Gastroenterology Association, Digestive Disease Week, 2019
  • Young Investigator Award, Summit Program in GD – Symposium on New Strategies for Multidisciplinary Cancer Research, 2018
  • Young Investigator Award, Hong Kong Immunology Forum, 2017
  • Best Poster Award, 21st ASM of Hong Kong Society of Flow Cytometry, 2016
  • National Scholar Award, United European Gastroenterology, 2015
  • Travel Award, United European Gastroenterology, 2015
  • Best Abstract Award, the 2nd World Congress on Controversies in Gastroenterology, 2014
  • Yu To Sang and Yu Shing Keung Memorial Fund Scholarship, 2012/2013
Professional Service
  • Editorial board member, Frontiers in Oncology
  • Member, the American Gastroenterological Association (AGA)
  • Member, Anti-Cancer Association of China
  • Member, Chronic Disease Management of China Medicinal Biotech Association
  • Secretary and Member, Cross-Strait Microbiological Cooperation Committee
  • Member, Hong Kong Society of Immunology
  • Member, Hong Kong Society of Flow Cytometry

Research and Publications

  1. Zhang X, Coker OO, Chu ESH, Fu K, Lau HCH, Wang YX, Chan AWH, Wei H, Yang X, Sung JJY, Yu J. Dietary cholesterol drives fatty liver-associated liver cancer by modulating gut microbiota and metabolites. Gut 2020 ; July 21. doi:10.1136/gutjnl-2019-319664.
  2. Zhang X, Fan L, Wu J, Xu H, Leung WY, Fu K, Wu J, Liu K, Kwan M, Yang X, Han J, Ren J, Yu J. Macrophage p38α promotes nutritional steatohepatitis through M1 polarization. J Hepatol 2019 ; 71(1):163-174.
  3. Han J, Zhang X# (Co-first author), Lau JKC, Fu K, Lau HCH, Xu W, Chu ESH, Lan H, Yu J. Bone marrow-derived macrophage contributes to fibrosing steatohepatitis through activating hepatic stellate cells. J Pathol 2019; 248(4):488-500.
  4. Wang X, Zhang X# (Co-first author), Chu ESH, Chen X, Kang W, Wu F, To KF, Wong VWS, Chan HLY, Chan MTV, Sung JJY, Wu WKK, Yu J. Defective lysosomal clearance of autophagosomes and its clinical implications in non-alcoholic steatohepatitis. FASEB J 2018;32(1):37-51.
  5. Zhang X, Wu WKK, Xu W, Man K, Wang X, Han J, Leung WY, Wu R, Liu K, Yu J. C-X-C Motif Chemokine 10 Impairs Autophagy and Autolysosome Formation in Non-alcoholic Steatohepatitis. Theranostics 2017;7(11):2822-2836.
  6. Du J, Zhang X# (Co-first author), Han J, Man K, Zhang Y, Chu ESH, Nan Y, Yu J. Pro-inflammatory CXCR3 impairs mitochondrial function in experimental non-alcoholic steatohepatitis. Theranostics 2017;7(17):4192-4203.
  7. Wong SH, Zhao L, Zhang X, Nakatsu G, Han J, Xu W, Xiao X, Kwong TN, Tsoi H, Wu WK, Benhua Z, Chan FK, Sung JJ, Wei H, Yu J, Gavage of Fecal Samples From Patients with Colorectal Cancer Promotes Intestinal Carcinogenesis in Germ-free and Conventional Mice. Gastroenterology 2017;153(6):1621-1633.e6.
  8. Xu W, Zhang X, Wu JL, Fu L, Liu K, Liu D, Chen GG, Lai PB, Wong N, Yu J. O-GlcNAc transferase promotes fatty liver-associated liver cancer through inducing palmitic acid and activating endoplasmic reticulum stress. J Hepatol 2017;67(2):310-320.
  9. Zhang X, Han J, Man K, Li X, Du J, Chu ES, Go MY, Sung JJ, Yu J. CXC chemokine receptor 3 promotes steatohepatitis in mice through mediating inflammatory cytokines, macrophages and autophagy. J Hepatol 2016; 64(1): 160-170.
  10. Zhang X Shen J, Man K, Chu ES, Yau TO, Sung JC, Go MY, Deng J, Lu J, Wong VW, Sung JJ, Farrell G, Yu J. CXCL10 plays a key role as an inflammatory mediator and a non-invasive biomarker of nonalcoholic steatohepatitis. J Hepatol 2014; 61 (6):1365-1375.

Prof Jennifer Xiang ZHANG

Research Assistant Professor

State Key Laboratory of Digestive Disease (CUHK)

Ms Cynthia Chi Fai TAI

Administrative and Communications Manager, Institute of Digestive Disease

Cynthia Tai is an Administrative and Communications Manager of the Institute of Digestive Disease (IDD), The Chinese University of Hong Kong. She graduated from the City University of Hong Kong and was awarded a Master’s Degree in Management. She is currently serving as Secretary of IDD Advisory Board and IDD Management Committee. She is responsible for managing the M.Sc. in Gastroenterology programme and implementing marketing plans. She also oversees the management of IDD HR, administration, financial and event planning. In addition, she is the Administrative Manager of the State Key Laboratory of Digestive Disease, CUHK.

Ms Cynthia C.F. TAI

Administrative and Communications Manager

Institute of Digestive Disease

Visiting Scholar

Dr HU Jielun

Visiting Scholar

jielunhu@cuhk.edu.hk

Nursing Staff

Ms CHIM Mei Ling Angel Nursing Officer 3505 3759 angelchim@cuhk.edu.hk
Ms LAM Chuen Hing Candice Nursing Officer 3505 2956 candicelam@surgery.cuhk.edu.hk
Ms SUEN Bing Yee Nursing Officer 3505 2931 suenbingyee@surgery.cuhk.edu.hk
Ms YUNG Man Yee Nursing Officer 3505 2956 myyung@surgery.cuhk.edu.hk
Ms SHU She Ting Sally Nurse 3505 4206 sallyshu@cuhk.edu.hk
Ms CHING Yuet Ling Jessica Honorary Chief Nursing Officer

jessicaching@cuhk.edu.hk

Post-doctoral Fellow

 

Dr JI Fenfen Post-doctoral Fellow 3763 6104 fenfenji@cuhk.edu.hk
Dr XIE Mingxu Max Post-doctoral Fellow mingxuxie@cuhk.edu.hk
Dr WEI Wenchao Post-doctoral Fellow wenchaowei@cuhk.edu.hk
Dr KANG Xing Jason Post-doctoral Fellow xingkang@cuhk.edu.hk
Dr ZHAO Liuyang Post-doctoral Fellow 3763 6104 liuyangzhao@cuhk.edu.hk
Dr ZHU Wenyi Post-doctoral Fellow wenyizhu@cuhk.edu.hk

Research Staff

Ms Whitney TANG Functional Manager whitneytang@cuhk.edu.hk
Ms Yue WU Research Associate yuetwu@cuhk.edu.hk
Mr Eagle CHU Research Associate 3763 6104 eagle_chu@cuhk.edu.hk
Mr Pete TSE Research Associate 3505 1208 petse@cuhk.edu.hk
Mr Y K TSE Research Associate 2637 3182 yktse@cuhk.edu.hk
Mr C P CHEUNG Senior Research Assistant cheungchunpan@cuhk.edu.hk
Mr K L IP Senior Research Assistant 3505 4319 longip@cuhk.edu.hk
Ms Ada CHAN Research Assistant adachan@cuhk.edu.hk
Ms Alicia CHAN Research Assistant 2637 3260 aliciachan@cuhk.edu.hk
Ms Moko CHEUNG Research Assistant 3505 3855 mokocheung@cuhk.edu.hk
Ms Julia CHIN Research Assistant 3505 4318 juliachin@cuhk.edu.hk
Mr Eric CHING Research Assistant ericching118@cuhk.edu.hk
Ms Emily CHIU Research Assistant 2637 3225 oileechiu@cuhk.edu.hk
Mr Alan CHU Research Assistant lokcheungchu@cuhk.edu.hk
Mr Tommy CHUN Research Assistant 3763 6104 tommychun@cuhk.edu.hk
Ms DIXON Sophie Maria Research Assistant sophiemariadixon@cuhk.edu.hk
Mr. DU Zibiao Research Assistant zibiaodu@cuhk.edu.hk
Ms Christy FONG Research Assistant 3505 1208 chinwaifong@cuhk.edu.hk
Ms Emily FUNG Research Assistant 2637 3225 yeetingfung@cuhk.edu.hk
Ms Suki HA Research Assistant sukiha@cuhk.edu.hk
Ms Serena HUEN Research Assistant 3505 4205 serenahuen@cuhk.edu.hk
Ms Krystal LEE Research Assistant hoitingkrystallee@cuhk.edu.hk
Ms Julie LEUNG Research Assistant 3505 4206 julieleung@cuhk.edu.hk
Ms Venus LI Research Assistant 2637 3225 venusli@cuhk.edu.hk
Ms Sarah LI Research Assistant huaningli@cuhk.edu.hk
Mr Louis LO Research Assistant 3505 3476 louislo@cuhk.edu.hk
Mr Victor MAN Research Assistant 2637 3260 panghoiman@cuhk.edu.hk
Ms Connie SETO Research Assistant waiyiseto@cuhk.edu.hk
Mr Felix SIA Research Assistant 2637 0428 felixsia@cuhk.edu.hk
Mr K W YAU Research Assistant kawingyau@cuhk.edu.hk
Ms Giann YEUNG Research Assistant 3505 3524 tszyanyeung@cuhk.edu.hk
Mr Jeffery YU Research Assistant jeffreyyu@cuhk.edu.hk
Ms Cherrie KEUNG Honorary Research Assistant cherriekeung@cuhk.edu.hk
Mr Timothy CHEUNG Junior Research Assistant 3505 4205 kamwingcheung@cuhk.edu.hk
Ms Kelly CHEUNG Junior Research Assistant 2637 3225 kellyywcheung@cuhk.edu.hk
Ms Maggie KOO Junior Research Assistant 2637 3225 maggiekoo@cuhk.edu.hk
Ms Sophia LAM Junior Research Assistant 3505 1208 sophia_lam@cuhk.edu.hk
Mr Lynuz TING Junior Research Assistant lynuzting@cuhk.edu.hk
Mr Andy WONG Junior Research Assistant wingchungwong@cuhk.edu.hk
Mr Michael WONG Junior Research Assistant 3505 3855 yaushingwong@cuhk.edu.hk
Ms Angel YANG Junior Research Assistant 3505 4318 onkeiangelyang@cuhk.edu.hk
Ms Katherine KWAN Senior Technician 3505 1208 katherinekwan@cuhk.edu.hk

Admin Staff

Ms Cynthia TAI Administrative and Communications Manager 2637 3209 ctai@cuhk.edu.hk
Mr Andrew HO Executive Officer 3505 2920 andrewho@cuhk.edu.hk
Ms Catherine CHAK Project Coordinator 3913 2394 catherinechak@cuhk.edu.hk
Ms Helen LAU Project Coordinator 2637 3201 helenlau@cuhk.edu.hk
Ms Mandy LEE Project Coordinator mandylee@cuhk.edu.hk
Mr Adam NG Project Coordinator 2637 3271 adamng@cuhk.edu.hk
Ms Ramcy NIP Project Coordinator 2637 3298 msnip@cuhk.edu.hk
Ms Michelle WONG Project Coordinator 2637 3272 twingwong@cuhk.edu.hk
Ms Catherine YUEN Project Coordinator 2637 3212 catherineyuen@cuhk.edu.hk
Ms Rainbow KONG Project Assistant 3763 6109 yuenchunkong@cuhk.edu.hk
Mr Jim CHIU Honorary Project Coordinator jimchiu@cuhk.edu.hk
Ms Olive YAU Project Assistant 3505 1298 oliveyau@cuhk.edu.hk
Ms Bonnie SIU Project Assistant 3505 1501 choyeesiu@cuhk.edu.hk
Ms Joey CHAN Clerical Assistant 2637 3260 joeychan16@cuhk.edu.hk
Ms Sarah CHAN Clerical Assistant saupingchan@cuhk.edu.hk
Ms Mandy LAU Clerical Assistant wmandylau@cuhk.edu.hk
Ms Gloria LEUNG Clerical Assistant mayfoonglorialeung@cuhk.edu.hk
Ms Canny SO Clerical Assistant 3505 4316 cannyso@cuhk.edu.hk
Mr Tony WONG Workman 3763 6104 twong@cuhk.edu.hk